CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation
المؤلفون المشاركون
Soldevila, Gloria
López-Pacheco, C.
Du Pont, G.
Hernández-Pando, Rogelio
García-Zepeda, E. A.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-04
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Airway inflammation is the most common hallmark of allergic asthma.
Chemokine receptors involved in leukocyte recruitment are closely related to the pathology in asthma.
CCR9 has been described as a homeostatic and inflammatory chemokine receptor, but its role and that of its ligand CCL25 during lung inflammation remain unknown.
To investigate the role of CCR9 as a modulator of airway inflammation, we established an OVA-induced allergic inflammation model in CCR9-deficient mice.
Here, we report the expression of CCR9 and CCL25 as early as 6 hours post-OVA challenge in eosinophils and T-lymphocytes.
Moreover, in challenged CCR9-deficient mice, cell recruitment was impaired at peribronchial and perivenular levels.
OVA-administration in CCR9-deficient mice leads to a less inflammatory cell recruitment, which modifies the expression of IL-10, CCL11, and CCL25 at 24 hours after OVA challenge.
In contrast, the secretion of IL-4 and IL-5 was not affected in CCR9-deficient mice compared to WT mice.
These results demonstrate for the first time that CCR9 and CCL25 expressions are induced in the early stages of airway inflammation and they have an important role modulating eosinophils and lymphocytes recruitment at the first stages of inflammatory process, suggesting that they might be a potential target to regulate inflammation in asthma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
López-Pacheco, C.& Soldevila, Gloria& Du Pont, G.& Hernández-Pando, Rogelio& García-Zepeda, E. A.. 2016. CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111024
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
López-Pacheco, C.…[et al.]. CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation. Mediators of Inflammation No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1111024
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
López-Pacheco, C.& Soldevila, Gloria& Du Pont, G.& Hernández-Pando, Rogelio& García-Zepeda, E. A.. CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111024
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111024
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر