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Peroxisome Proliferator-Activated Receptor α Reduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin
المؤلفون المشاركون
Liu, Po-Len
Jen, Hsu-Lung
Yin, Wei-Hsian
Lin, Shing-Jong
Chen, J.-W.
Chen, Yung-Hsiang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-11
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Peroxisome proliferator-activated receptor α (PPARα) plays a role in the pathogenesis of cardiac hypertrophy, although its underlying mechanism remains unclear.
The purpose of this study was to evaluate the effect of PPARα activation on endothelin-1- (ET-1-) caused cardiomyocyte hypertrophy and explore its underlying mechanisms.
Human cardiomyocytes (HCMs) were cultured with or without ET-1, whereafter the inhibitory effects of fenofibrate, a PPARα activator, on cell size and adiponectin protein were tested.
We examined the activation of extracellular signal-regulated kinase (ERK) and p38 proteins caused by ET-1 and the inhibition of the ERK and p38 pathways on ET-1-induced cell size and adiponectin expression.
Moreover, we investigated the interaction of PPARα with adiponectin and nuclear factor-κB (NF-κB) by electrophoretic mobility shift assays and coimmunoprecipitation.
ET-1 treatment significantly increased cell size, suppressed PPARα expression, and enhanced the expression of adiponectin.
Pretreatment with fenofibrate inhibited the increase in cell size and enhancement of adiponectin expression.
ET-1 significantly activated the ERK and p38 pathways, whereas PD98059 and SB205380, respectively, inhibited them.
Our results suggest that activated PPARα can decrease activation of adiponectin and NF-κB and inhibit ET-1-induced cardiomyocyte hypertrophy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jen, Hsu-Lung& Liu, Po-Len& Chen, Yung-Hsiang& Yin, Wei-Hsian& Chen, J.-W.& Lin, Shing-Jong. 2016. Peroxisome Proliferator-Activated Receptor α Reduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jen, Hsu-Lung…[et al.]. Peroxisome Proliferator-Activated Receptor α Reduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jen, Hsu-Lung& Liu, Po-Len& Chen, Yung-Hsiang& Yin, Wei-Hsian& Chen, J.-W.& Lin, Shing-Jong. Peroxisome Proliferator-Activated Receptor α Reduces Endothelin-1-Caused Cardiomyocyte Hypertrophy by Inhibiting Nuclear Factor-κB and Adiponectin. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1111109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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