Higher Urinary Levels of 8-Hydroxy-2′-deoxyguanosine Are Associated with a Worse RANKLOPG Ratio in Postmenopausal Women with Osteopenia
المؤلفون المشاركون
Romani, Arianna
Greco, Pantaleo
Cremonini, Eleonora
Bergamini, Carlo M.
Fila, Enrica
Squerzanti, Monica
Bonaccorsi, Gloria
Massari, Leo
Cervellati, Carlo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Postmenopausal osteoporosis (PO) is a major public health issue which affects a large fraction of elderly women.
Emerging in vitro evidence suggests a central role of oxidative stress (OxS) in postmenopausal osteoporosis (PO) development.
Contrariwise, the human studies on this topic are still scarce and inconclusive.
In the attempt to address this issue, we sought to determine if OxS, as assessed by 8-hydroxy-2-deoxyguanosine (8-OHdG), may influence the level of receptor activator of nuclear factor-κb ligand (RANKL)/osteoprotegerin (OPG) ratio (a central regulator of bone metabolism) in a sample n=124, including postmenopausal women with osteoporosis, osteopenia and normal bone mass density (BMD).
The most striking result that emerged in our study was the independent and positive (beta = 0.449, p=0.004, and R2=0.185) association between the OxS marker and RANKL/OPG ratio which was found in osteopenic but not in the other 2 sample groups.
If confirmed by longitudinal studies, our findings would suggest that OxS is implicated in the derangement of bone homeostasis which precedes PO development.
In line with these considerations, antioxidant treatment of postmenopausal women with moderately low BMD might contribute to preventing PO and related complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cervellati, Carlo& Romani, Arianna& Cremonini, Eleonora& Bergamini, Carlo M.& Fila, Enrica& Squerzanti, Monica…[et al.]. 2015. Higher Urinary Levels of 8-Hydroxy-2′-deoxyguanosine Are Associated with a Worse RANKLOPG Ratio in Postmenopausal Women with Osteopenia. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114077
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cervellati, Carlo…[et al.]. Higher Urinary Levels of 8-Hydroxy-2′-deoxyguanosine Are Associated with a Worse RANKLOPG Ratio in Postmenopausal Women with Osteopenia. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114077
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cervellati, Carlo& Romani, Arianna& Cremonini, Eleonora& Bergamini, Carlo M.& Fila, Enrica& Squerzanti, Monica…[et al.]. Higher Urinary Levels of 8-Hydroxy-2′-deoxyguanosine Are Associated with a Worse RANKLOPG Ratio in Postmenopausal Women with Osteopenia. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114077
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114077
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر