Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats
المؤلفون المشاركون
Pokkunuri, Indira
Ali, Quaisar
Asghar, Mohammad
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
We examined the effects and mechanism of grape powder- (GP-) mediated improvement, if any, on aging kidney function.
Adult (3-month) and aged (21-month) Fischer 344 rats were treated without (controls) and with GP (1.5% in drinking water) and kidney parameters were measured.
Control aged rats showed higher levels of proteinuria and urinary kidney injury molecule-1 (KIM-1), which decreased with GP treatment in these rats.
Renal protein carbonyls (protein oxidation) and gp 91phox-NADPH oxidase levels were high in control aged rats, suggesting oxidative stress burden in these rats.
GP treatment in aged rats restored these parameters to the levels of adult rats.
Moreover, glomerular filtration rate and sodium excretion were low in control aged rats suggesting compromised kidney function, which improved with GP treatment in aged rats.
Interestingly, low renal mitochondrial respiration and ATP levels in control aged rats were associated with reduced levels of mitochondrial biogenesis marker MtTFA.
Also, Nrf2 proteins levels were reduced in control aged rats.
GP treatment increased levels of MtTFA and Nrf2 in aged rats.
These results suggest that GP by potentially regulating Nrf2 improves aging mitochondrial and kidney functions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pokkunuri, Indira& Ali, Quaisar& Asghar, Mohammad. 2016. Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114085
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pokkunuri, Indira…[et al.]. Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114085
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pokkunuri, Indira& Ali, Quaisar& Asghar, Mohammad. Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114085
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114085
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر