Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids
المؤلفون المشاركون
Pinna, Roberto
Milia, Egle
Delitala, Alessandro P.
Maioli, Margherita
Basoli, Valentina
Santaniello, Sara
Cruciani, Sara
Grillari-Voglauer, Regina
Fontani, Vania
Rinaldi, Salvatore
Muggironi, Roberta
Pigliaru, Gianfranco
Ventura, Carlo
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-10
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Human dental pulp stem cells (hDPSCs) have shown relevant potential for cell therapy in the orthopedic and odontoiatric fields.
The optimization of their osteogenic potential is currently a major challenge.
Vascular endothelial growth factor A (VEGF A) has been recently reported to act as a major conductor of osteogenesis in vitro and in vivo.
Here, we attempted to prime endogenous VEGF A expression without the need for viral vector mediated gene transfer technologies.
We show that hDPSCs exposure to a mixture of hyaluronic, butyric, and retinoic acids (HA + BU + RA) induced the transcription of a gene program of osteogenesis and the acquirement of an osteogenic lineage.
Such response was also elicited by cell exposure to melatonin, a pleiotropic agent that recently emerged as a remarkable osteogenic inducer.
Interestingly, the commitment to the osteogenic fate was synergistically enhanced by the combinatorial exposure to a conditioned medium containing both melatonin and HA + BU + RA.
These in vitro results suggest that in vivo osteogenesis might be improved and further studies are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Maioli, Margherita& Basoli, Valentina& Santaniello, Sara& Cruciani, Sara& Delitala, Alessandro P.& Pinna, Roberto…[et al.]. 2016. Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116179
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maioli, Margherita…[et al.]. Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116179
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Maioli, Margherita& Basoli, Valentina& Santaniello, Sara& Cruciani, Sara& Delitala, Alessandro P.& Pinna, Roberto…[et al.]. Osteogenesis from Dental Pulp Derived Stem Cells: A Novel Conditioned Medium Including Melatonin within a Mixture of Hyaluronic, Butyric, and Retinoic Acids. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116179
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116179
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر