Wound Dressing Model of Human Umbilical Cord Mesenchymal Stem Cells-Alginates Complex Promotes Skin Wound Healing by Paracrine Signaling
المؤلفون المشاركون
Wang, Song
Yang, Huachao
Tang, Zhenrui
Long, Gang
Huang, Wen
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-31
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Purpose.
To probe growth characteristics of human umbilical cord mesenchymal stem cells (hUCMSCs) cultured with alginate gel scaffolds, and to explore feasibility of wound dressing model of hUCMSCs-alginates compound.
Methods.
hUCMSCs were isolated, cultured, and identified in vitro.
Then cells were cultivated in 100 mM calcium alginate gel, and the capacity of proliferation and migration and the expression of vascular endothelial growth factors (VEGF) were investigated regularly.
Wound dressing model of hUCMSCs-alginate gel mix was transplanted into Balb/c mice skin defects.
Wound healing rate and immunohistochemistry were examined.
Results.
hUCMSCs grew well but with little migration ability in the alginate gel.
Compared with control group, a significantly larger cell number and more VEGF expression were shown in the gel group after culturing for 3–6 days (P < 0.05).
In addition, a faster skin wound healing rate with more neovascularization was observed in the hUCMSCs-alginate gel group than in control groups at 15th day after surgery (P < 0.05).
Conclusion.
hUCMSCs can proliferate well and express massive VEGF in calcium alginate gel porous scaffolds.
Wound dressing model of hUCMSCs-alginate gel mix can promote wound healing through paracrine signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Song& Yang, Huachao& Tang, Zhenrui& Long, Gang& Huang, Wen. 2015. Wound Dressing Model of Human Umbilical Cord Mesenchymal Stem Cells-Alginates Complex Promotes Skin Wound Healing by Paracrine Signaling. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116372
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Song…[et al.]. Wound Dressing Model of Human Umbilical Cord Mesenchymal Stem Cells-Alginates Complex Promotes Skin Wound Healing by Paracrine Signaling. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116372
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Song& Yang, Huachao& Tang, Zhenrui& Long, Gang& Huang, Wen. Wound Dressing Model of Human Umbilical Cord Mesenchymal Stem Cells-Alginates Complex Promotes Skin Wound Healing by Paracrine Signaling. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116372
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116372
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر