Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials
المؤلفون المشاركون
Moniche, Francisco
Escudero, Irene
Zapata, Elena
de la Torre Laviana, Francisco Javier
Carmona, Magdalena
Piñero, Pilar
Bustamante, Alejandro
Lebrato, Lucía
Cabezas, Juan Antonio
Gonzalez, Alejandro
Montaner, Joan
de Freitas, Gabriel Rodriguez
Rosado-de-Castro, Paulo Henrique
Mendez-Otero, Rosalia
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-21
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Background and Purpose.
BM-MNC transplantation improves recovery in experimental models of ischemic stroke.
Clinical trials are ongoing to test efficacy in stroke patients.
However, whether cell dose is related to outcomes is not known.
Methods.
We performed a pooling data analysis of two pilot clinical trials with autologous BM-MNCs transplantation in ischemic stroke patients.
Cell dose and route were analyzed to evaluate their relation to good outcome (m-Rankin scale [mRS] score 0–2) at 6 months.
Results.
Twenty-two patients were included.
A median of 153 × 106 (±121 × 106) BM-MNCs was injected.
Intra-arterial route was used in 77.3% of cases.
A higher number of cells injected were associated with better outcomes at 180 days (390 × 106 [320–422] BM-MNCs injected in those patients with mRS of 0–2 at 6 months versus 130 × 106 [89–210] in those patients with mRS 3–6, p = 0.015 ).
In the intra-arterially treated patients, a strong correlation between dose of cells and disability was found ( r = - 0.63 , p = 0.006 ).
A cut point of 310 × 106 injected cells predicted good outcome with 80% sensitivity and 88.2% specificity.
Conclusions.
Similar to preclinical studies, a higher dose of autologous BM-MNC was related to better outcome in stroke patients, especially when more than 310 × 106 cells are injected.
Further interventional studies are warranted to confirm these data.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moniche, Francisco& Rosado-de-Castro, Paulo Henrique& Escudero, Irene& Zapata, Elena& de la Torre Laviana, Francisco Javier& Mendez-Otero, Rosalia…[et al.]. 2016. Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moniche, Francisco…[et al.]. Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1117319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moniche, Francisco& Rosado-de-Castro, Paulo Henrique& Escudero, Irene& Zapata, Elena& de la Torre Laviana, Francisco Javier& Mendez-Otero, Rosalia…[et al.]. Increasing Dose of Autologous Bone Marrow Mononuclear Cells Transplantation Is Related to Stroke Outcome: Results from a Pooled Analysis of Two Clinical Trials. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1117319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر