Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation
المؤلفون المشاركون
Hsia, Chih-Hsuan
Shyu, Ren-Shi
Khamrang, Themmila
Hsia, Chih-Wei
Velusamy, Marappan
Chou, Duen-Suey
Sheu, Joen-Rong
Chang, Chao-Chien
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-02
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Platelet activation has been reported to play a major role in arterial thrombosis, cancer metastasis, and progression.
Recently, we developed a novel Ir(III)-based compound, [Ir(Cp∗)1-(2-pyridyl)-3-(4-dimethylaminophenyl)imidazo[1,5-a]pyridine Cl]BF4 or Ir-6 and assessed its effectiveness as an antiplatelet drug.
Ir-6 exhibited higher potency against human platelet aggregation stimulated by collagen.
Ir-6 also inhibited ATP-release, intracellular Ca2+ mobilization, P-selectin expression, and the phosphorylation of phospholipase Cγ2 (PLCγ2), protein kinase C (PKC), v-Akt murine thymoma viral oncogene (Akt)/protein kinase B, and mitogen-activated protein kinases (MAPKs), in collagen-activated platelets.
Neither the adenylate cyclase inhibitor SQ22536 nor the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one significantly reversed the Ir-6-mediated inhibition of collagen-induced platelet aggregation.
Moreover, Ir-6 did not considerably diminish OH radical signals in collagen-activated platelets or Fenton reaction solution.
At 2 mg/kg, Ir-6 markedly prolonged the bleeding time in experimental mice.
In conclusion, Ir-6 plays a crucial role by inhibiting platelet activation through the inhibition of signaling pathways, such as the PLCγ2–PKC cascade and the subsequent suppression of Akt and MAPK activation, thereby ultimately inhibiting platelet aggregation.
Therefore, Ir-6 is a potential therapeutic agent for preventing or treating thromboembolic disorders or disrupting the interplay between platelets and tumor cells, which contributes to tumor cell growth and progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shyu, Ren-Shi& Khamrang, Themmila& Sheu, Joen-Rong& Hsia, Chih-Wei& Velusamy, Marappan& Hsia, Chih-Hsuan…[et al.]. 2018. Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation. Bioinorganic Chemistry and Applications،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1123214
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shyu, Ren-Shi…[et al.]. Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation. Bioinorganic Chemistry and Applications No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1123214
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shyu, Ren-Shi& Khamrang, Themmila& Sheu, Joen-Rong& Hsia, Chih-Wei& Velusamy, Marappan& Hsia, Chih-Hsuan…[et al.]. Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation. Bioinorganic Chemistry and Applications. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1123214
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1123214
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر