The Effect of Carbogen Breathing on 18F-FDG Uptake in Non-Small-Cell Lung Cancer
المؤلفون المشاركون
Lin, Yu
Bao, Ying-Na
Huang, Cong-Xiu
Zhang, Ji-Hong
Yu, Zhi-Long
Tian, Ye
Wang, Xiang-Cheng
Cui, Yi-Tong
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
It has been reported that 18F-FDG uptake is higher in hypoxic cancer cells than in well-oxygenated cells.
We demonstrated that 18F-FDG uptake in lung cancer would be affected by high concentration oxygen breathing.
Methods.
Overnight fasted non-small-cell lung cancer A549 subcutaneous (s.c.) xenografts bearing mice (n = 10) underwent 18F-FDG micro-PET scans, animals breathed room air on day 1, and same animals breathed carbogen (95% O2 + 5% CO2) on the subsequent day.
In separated studies, autoradiography and immunohistochemical staining visualization of frozen section of A549 s.c.
tumors were applied, and to compare between carbogen-breathing mice and those with air breathing, a combination of 18F-FDG and hypoxia marker pimonidazole was injected 1 h before animal sacrifice, and 18F-FDG accumulation was compared with pimonidazole binding and glucose transporter 1 (GLUT-1) expression.
Results.
PET studies revealed that tumor 18F-FDG uptake was significantly decreased in carbogen-breathing mice than those with air breathing (P<0.05).
Ex vivo studies confirmed that carbogen breathing significantly decreased hypoxic fraction detected by pimonidazole staining, referring to GLUT-1 expression, and significantly decreased 18F-FDG accumulation in tumors.
Conclusions.
High concentration of O2 breathing during 18F-FDG uptake phase significantly decreases 18F-FDG uptake in non-small-cell lung cancer A549 xenografts growing in mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Yu& Bao, Ying-Na& Huang, Cong-Xiu& Zhang, Ji-Hong& Yu, Zhi-Long& Tian, Ye…[et al.]. 2019. The Effect of Carbogen Breathing on 18F-FDG Uptake in Non-Small-Cell Lung Cancer. BioMed Research International،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124171
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Yu…[et al.]. The Effect of Carbogen Breathing on 18F-FDG Uptake in Non-Small-Cell Lung Cancer. BioMed Research International No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1124171
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Yu& Bao, Ying-Na& Huang, Cong-Xiu& Zhang, Ji-Hong& Yu, Zhi-Long& Tian, Ye…[et al.]. The Effect of Carbogen Breathing on 18F-FDG Uptake in Non-Small-Cell Lung Cancer. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1124171
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1124171
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر