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Glutamine Improves Oxidative Stress through the Wnt3aβ-Catenin Signaling Pathway in Alzheimer’s Disease In Vitro and In Vivo
المؤلفون المشاركون
Wang, Yuan
Wang, Qiang
Li, Jie
Lu, Gang
Liu, Zhibin
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background/Aims.
Alzheimer’s disease (AD) is the most common neurodegenerative disease, and all researchers working in this field agree that oxidative stress is intimately associated with Alzheimer disease.
In this study, we hypothesized that glutamine (Gln) offers protection against oxidative stress injury in SAMP8 mice as well as the underlying mechanism.
Methods.
The SAMP8 mice received glutamine intragastrically for 8 consecutive weeks to evaluate the protective effect of glutamine on oxidative stress in AD mice involving Wnt3a/β-catenin signaling pathway.
In addition, rat pheochromocytoma tumor cell line PC12 was pretreated with 32 μM glutamine for 2 h followed by 24 h incubation with 40 μM Aβ25-35 to obtain in vitro data.
Results.
In vivo the administration of glutamine was found to ameliorate behavioral deficits and neuron damage, increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-XP) activity, reduce the malondialdehyde (MDA) content, and activate the Wnt3a/β-catenin signaling pathway in SAMP8 mice.
In vitro glutamine treatment decreased the toxicity of Aβ25-35 on PC12 cells and prevented apoptosis.
Additionally, glutamine treatment increased SOD and GSH-XP activity and decreased MDA content and increased Wnt3a and β-catenin protein levels.
Interestingly, the DKK-1 (Wnt3a/β-catenin pathway inhibitor) decreased the antioxidant capacity of glutamine in Aβ25-35-treated PC12 cells.
Conclusion.
This study suggests that glutamine could protect against oxidative stress-induced injury in AD mice via the Wnt3a/β-catenin signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yuan& Wang, Qiang& Li, Jie& Lu, Gang& Liu, Zhibin. 2019. Glutamine Improves Oxidative Stress through the Wnt3aβ-Catenin Signaling Pathway in Alzheimer’s Disease In Vitro and In Vivo. BioMed Research International،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125521
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yuan…[et al.]. Glutamine Improves Oxidative Stress through the Wnt3aβ-Catenin Signaling Pathway in Alzheimer’s Disease In Vitro and In Vivo. BioMed Research International No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1125521
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yuan& Wang, Qiang& Li, Jie& Lu, Gang& Liu, Zhibin. Glutamine Improves Oxidative Stress through the Wnt3aβ-Catenin Signaling Pathway in Alzheimer’s Disease In Vitro and In Vivo. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1125521
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125521
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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