An Investigation on the Therapeutic Effect of Thymosin β 4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice
المؤلفون المشاركون
Lee, Sang Ho
Kim, Dong-Jin
Cho, Kyung Sook
Shim, Bomee
Kim, Jung Yeon
Kang, Jun Mo
Park, Seon Hwa
Yang, Hyung-In
Kim, Kyoung Soo
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Thymosin β4 (Tβ4) treatment was known to show the potential therapeutic effects on diabetic complications.
This study was performed to determine if Tβ4 expression is changed in both serum and tissues under diabetic conditions and can be a serum biomarker.
Type 1 diabetic mice were induced in C57/BL6J mice by intraperitoneal injection of streptozotocin (STZ) at a dose of 50 mg/kg body weight.
The mice were sacrificed at 16 weeks after STZ injection.
Tissues and plasmas were obtained to determine the expression levels of Tβ4 using ELISA, real time RT-PCR, and immunohistochemistry.
The average serum glucose level was increased to approximately 400 mg/dL beginning 2 weeks after the five injections of STZ and lasting for at least 13 weeks until sacrifice.
The plasma and tissue levels of Tβ4 in the age-matched control mice were not significantly different from those of the diabetic mice.
In conclusion, the Tβ4 expression level in the plasmas and tissues of diabetic mice was not affected by diabetic conditions.
It indirectly suggests that the therapeutic effect of Tβ4 on diabetic complications is due to its regenerative effects on damaged tissue but not to the changed expression level of Tβ4 in plasma and tissues of diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cho, Kyung Sook& Kim, Dong-Jin& Shim, Bomee& Kim, Jung Yeon& Kang, Jun Mo& Park, Seon Hwa…[et al.]. 2018. An Investigation on the Therapeutic Effect of Thymosin β 4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cho, Kyung Sook…[et al.]. An Investigation on the Therapeutic Effect of Thymosin β 4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1125800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cho, Kyung Sook& Kim, Dong-Jin& Shim, Bomee& Kim, Jung Yeon& Kang, Jun Mo& Park, Seon Hwa…[et al.]. An Investigation on the Therapeutic Effect of Thymosin β 4 and Its Expression Levels in Streptozotocin-Induced Diabetic Mice. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1125800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1125800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر