Corticosteroids for Graves’ Ophthalmopathy: Systematic Review and Meta-Analysis
المؤلفون المشاركون
Tu, Xiaofang
Dong, Yan
Zhang, Hongmei
Su, Qing
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Graves’ ophthalmopathy (GO) is a complicated autoimmune disease.
Various therapies have been used to manage GO; however the optimum therapy is not clear.
Glucocorticoids (GCs) therapy is the mainstay of treatment especially for active moderate to severe patients, which needs evidence-based support.
Method.
We searched all the randomized controlled trials (RCTs) involving corticosteroid treatment for patients diagnosed with GO from EMBASE, Medline, and the Cochrane library and then conducted a system review and meta-analysis.
The electronic search covered the period from April 1966 to March 2018.
Result.
Twenty-nine trials were included.
GCs were proved to be beneficial for GO patients [response rate, risk ratio (RR) = 1.72, 95% confidence interval (CI): 1.28~2.31, P=0.0003], and intravenous corticosteroids worked significantly better than oral corticosteroids as ever reported.
When compared with the single treatment of GCs, the combination of radiotherapy and GCs showed similar effects on response rate (RR=1.25, 95%CI: 0.91~1.73).
A study proved the advantage of mycophenolate mofetil over GCs in three outcomes (response rate, RR=0.74, 95%CI: 0.63~0.88).
Additional treatments such as technetium-99 methylene diphosphate (99Tc-MDP) or cyclosporine enhanced the effect of GCs on proptosis reduction, respectively (P<0.00001 and P=0.02).
Conclusion.
Our meta-analysis confirmed the effects of GCs in the management of GO and intravenous GCs are proved to be better than oral GCs as ever reported.
Combination of radiotherapy and GCs did not enhance the effects of GCs.
However, if proptosis is the main issue, combination of 99Tc-MDP or cyclosporine with GCs may be taken into consideration.
The reported advantages of mycophenolate mofetil over GCs are noteworthy and need more RCTs to confirm.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tu, Xiaofang& Dong, Yan& Zhang, Hongmei& Su, Qing. 2018. Corticosteroids for Graves’ Ophthalmopathy: Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126946
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tu, Xiaofang…[et al.]. Corticosteroids for Graves’ Ophthalmopathy: Systematic Review and Meta-Analysis. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1126946
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tu, Xiaofang& Dong, Yan& Zhang, Hongmei& Su, Qing. Corticosteroids for Graves’ Ophthalmopathy: Systematic Review and Meta-Analysis. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1126946
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1126946
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر