Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma
المؤلفون المشاركون
Wang, Hongming
Xue, Weishuang
Jiang, Xuejun
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
TRIM24 (Tripartite Motif Containing 24) is a recently identified oncogene overexpressed in various cancers.
However, the molecular mechanism of TRIM24 in the progression of head and neck squamous cell carcinoma (HNSCC) remains ambiguous.
In the present study, we analyzed the expression pattern of TRIM24 in 100 HNSCC tissues and found that TRIM24 was overexpressed in 43/100 HNSCC cases.
Significant association was found between TRIM24 overexpression and tumor-node-metastasis (TNM) stage (p=0.0034) and T stage (p=0.0048).
Furthermore, we overexpressed and knocked down TRIM24 in Detroit 562 and FaDu cell lines, respectively.
TRIM24 overexpression promoted proliferation, colony formation, and invasion, while TRIM24 depletion inhibited proliferation, colony formation, and invasion.
Further studies showed that TRIM24 facilitated cell cycle transition and upregulated cyclin D1 and p-Rb.
In addition, we found that GLUT3, a key protein involved in regulating glucose metabolism, was altered in HNSCC cells overexpressing TRIM24.
We demonstrated that TRIM24 overexpression increased glucose uptake ATP production.
Overexpression of TRIM24 increases cell sensitivity to glucose deprivation in Detroit cells.
Depleting TRIM24 in FaDu cells demonstrated the opposite results.
We also showed that TRIM24 could bind to the promoter region of cyclin D1.
In conclusion, TRIM24 is upregulated in HNSCC and promotes HNSCC cell growth and invasion through modulation of cell cycle, glucose metabolism, and GLUT3, making TRIM24 a potential oncoprotein in HNSCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hongming& Xue, Weishuang& Jiang, Xuejun. 2018. Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma. BioMed Research International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127716
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hongming…[et al.]. Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma. BioMed Research International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1127716
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hongming& Xue, Weishuang& Jiang, Xuejun. Overexpression of TRIM24 Stimulates Proliferation and Glucose Metabolism of Head and Neck Squamous Cell Carcinoma. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1127716
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127716
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر