Human Systems Biology and Metabolic Modelling: A Review—From Disease Metabolism to Precision Medicine
المؤلف
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-09
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
In cell and molecular biology, metabolism is the only system that can be fully simulated at genome scale.
Metabolic systems biology offers powerful abstraction tools to simulate all known metabolic reactions in a cell, therefore providing a snapshot that is close to its observable phenotype.
In this review, we cover the 15 years of human metabolic modelling.
We show that, although the past five years have not experienced large improvements in the size of the gene and metabolite sets in human metabolic models, their accuracy is rapidly increasing.
We also describe how condition-, tissue-, and patient-specific metabolic models shed light on cell-specific changes occurring in the metabolic network, therefore predicting biomarkers of disease metabolism.
We finally discuss current challenges and future promising directions for this research field, including machine/deep learning and precision medicine.
In the omics era, profiling patients and biological processes from a multiomic point of view is becoming more common and less expensive.
Starting from multiomic data collected from patients and N-of-1 trials where individual patients constitute different case studies, methods for model-building and data integration are being used to generate patient-specific models.
Coupled with state-of-the-art machine learning methods, this will allow characterizing each patient’s disease phenotype and delivering precision medicine solutions, therefore leading to preventative medicine, reduced treatment, and in silico clinical trials.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Angione, Claudio. 2019. Human Systems Biology and Metabolic Modelling: A Review—From Disease Metabolism to Precision Medicine. BioMed Research International،Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1127852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Angione, Claudio. Human Systems Biology and Metabolic Modelling: A Review—From Disease Metabolism to Precision Medicine. BioMed Research International No. 2019 (2019), pp.1-16.
https://search.emarefa.net/detail/BIM-1127852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Angione, Claudio. Human Systems Biology and Metabolic Modelling: A Review—From Disease Metabolism to Precision Medicine. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-16.
https://search.emarefa.net/detail/BIM-1127852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1127852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر