Condylar Degradation from Decreased Occlusal Loading following Masticatory Muscle Atrophy
المؤلفون المشاركون
Zheng, Li Wu
Shi, Zhan
Lv, Jin
Xiaoyu, Liu
Yang, Xue-wen
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
The masticatory muscles are the most important contributor to bite force, and the temporomandibular joint (TMJ) receives direct occlusal loading.
The present study aimed to investigate condylar remodeling after masseter muscle atrophy in rats.
Methods.
Sixty 5-week-old female Sprague-Dawley rats were divided into the following 3 groups: the control group, soft diet (SD) group, and botulinum toxin (BTX) group.
The cross-sectional area (CSA) of the masseter muscles was investigated as well as atrogin-1/MuRF-1 expression.
Changes in the condylar head were evaluated by H-E, toluidine blue staining, and contour measurements.
The biomechanical sensitive factors PTHrP Ihh, Col2a1, and ColX of condylar cartilage were detected by immunohistochemical staining and western blotting.
Furthermore, micro-CT and tartrate-resistant acid phosphatase (TRAP) staining were performed to determine the osteopenia in subchondral bone.
Results.
The histological and protein analysis demonstrated muscle hypofunction in the SD and BTX groups.
Condylar cartilage contour was diminished due to different treatments; the immunohistochemistry and protein examination showed that the expressions of PTHrP, Ihh, Col2a1, and ColX were suppressed in condylar cartilage.
A steady osteoporosis in subchondral bone was found only in the BTX group.
Conclusion.
The current results suggested that a steady relationship between muscular dysfunction and condylar remodeling exists.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shi, Zhan& Lv, Jin& Xiaoyu, Liu& Zheng, Li Wu& Yang, Xue-wen. 2018. Condylar Degradation from Decreased Occlusal Loading following Masticatory Muscle Atrophy. BioMed Research International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shi, Zhan…[et al.]. Condylar Degradation from Decreased Occlusal Loading following Masticatory Muscle Atrophy. BioMed Research International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1128183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shi, Zhan& Lv, Jin& Xiaoyu, Liu& Zheng, Li Wu& Yang, Xue-wen. Condylar Degradation from Decreased Occlusal Loading following Masticatory Muscle Atrophy. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1128183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر