The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells
المؤلفون المشاركون
Cheng, Xuan
Zhang, Lu
Lian, Ya-Jun
Fang, Yu
Zeng, Zhaoshu
Wu, Chuanjie
Zhu, Hongcan
Xu, Hongliang
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
We aimed to investigate the effect and mechanism of curcumin (CUR) in Alzheimer’s disease (AD).
Methods.
Mouse hippocampal neuronal cell line HT-22 was treated with Aβ1–42 and/or CUR, and then cell viability was evaluated by cell counting kit 8, Beclin-l level was detected using western blotting, and the formation of autophagosomes was observed by transmission electron microscopy (TEM).
Furthermore, transcriptome sequencing and analysis were performed in cells with Aβ1–42 alone or Aβ1–42 + CUR.
Results.
Aβ1–42 treatment significantly inhibited cell viability compared with untreated cells (P<0.01).
After treatment for 48 h, CUR remarkably promoted cell viability compared with cell treated with Aβ1–42 alone (P<0.01).
Compared with cells treated with Aβ1–42 alone, the expression of Beclin-1 was slightly reduced in cells with combined treatment of Aβ1–42 with CUR (P<0.05).
Consistently, TEM results showed that CUR inhibited the formation of autophagosomes in cells treated with Aβ1–42.
Furthermore, the protein-protein interaction network showed five key genes, including MYC, Cdh1, Acaca, Egr1, and CCnd1, likely involved in CUR effects.
Conclusions.
CUR might have a potential neuroprotective effect by promoting cell viability in AD, which might be associated with cell autophagy.
Furthermore, MYC, Cdh1, and Acaca might be involved in the progression of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lu& Fang, Yu& Cheng, Xuan& Lian, Ya-Jun& Zeng, Zhaoshu& Wu, Chuanjie…[et al.]. 2018. The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells. BioMed Research International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lu…[et al.]. The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells. BioMed Research International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1128909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lu& Fang, Yu& Cheng, Xuan& Lian, Ya-Jun& Zeng, Zhaoshu& Wu, Chuanjie…[et al.]. The Potential Protective Effect of Curcumin on Amyloid-β-42 Induced Cytotoxicity in HT-22 Cells. BioMed Research International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1128909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1128909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر