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CZYH Alleviates β-Amyloid-Induced Cognitive Impairment and Inflammation Response via Modulation of JNK and NF-κB Pathway in Rats
المؤلفون المشاركون
Gong, Qi-hai
Deng, Yuanyuan
Ye, Lianzhi
Yu, Cheng
Yin, Caixia
Shi, Jing-Shan
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-04
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cu-Zhi-Yi-Hao (CZYH), an empirical formula of traditional Chinese medicine (TCM), has been used for amnesia treatment in clinical practice.
However, its underlying pharmacological mechanism has not been fully illuminated.
The current study was designed to investigate the neuroprotective effect of CZYH on a β-amyloid 25-35- (Aβ25-35-) induced learning and memory deficit rat model.
CZYH (200, 400, or 800 mg/kg), donepezil (1.0 mg/kg), or distilled water was given to Aβ25-35-stimulated animals for 17 days consecutively.
The Morris water maze test revealed that CZYH (400 or 800 mg/kg) administration improved the Aβ25-35-induced cognitive impairments in rats, and Nissl staining demonstrated that CZYH mitigated the Aβ-caused neuron loss.
In addition, CZYH treatment markedly inhibited the activation of microglia as evidenced by a decreased level of IBA-1 and increased YM-1/2 protein expression.
The protein expression levels of TNF-α, IL-1β, and COX-2 were also repressed by CZYH.
Besides, CZYH treatment alleviated Aβ-induced IκB-α degradation and NF-κB p65 phosphorylation, as well as reduced the JNK phosphorylation level.
In conclusion, the present study suggests that CZYH could improve learning and memory abilities and relieve neuron loss in Aβ25-35-induced rats, at least partly through inhibition of the neuroinflammatory response via inhibiting the JNK-dependent NF-κB activation, indicating that CZYH might be a promising formula for the treatment of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Yuanyuan& Ye, Lianzhi& Yu, Cheng& Yin, Caixia& Shi, Jing-Shan& Gong, Qi-hai. 2019. CZYH Alleviates β-Amyloid-Induced Cognitive Impairment and Inflammation Response via Modulation of JNK and NF-κB Pathway in Rats. Behavioural Neurology،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1129055
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Yuanyuan…[et al.]. CZYH Alleviates β-Amyloid-Induced Cognitive Impairment and Inflammation Response via Modulation of JNK and NF-κB Pathway in Rats. Behavioural Neurology No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1129055
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Yuanyuan& Ye, Lianzhi& Yu, Cheng& Yin, Caixia& Shi, Jing-Shan& Gong, Qi-hai. CZYH Alleviates β-Amyloid-Induced Cognitive Impairment and Inflammation Response via Modulation of JNK and NF-κB Pathway in Rats. Behavioural Neurology. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1129055
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129055
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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