Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study
المؤلفون المشاركون
Routsi, C.
Nanas, S.
Tzanis, Georgios
Angelopoulos, Epameinondas
Kaltsi, Ifigeneia
Sideris, Antonios
Tyrovolas, Konstantinos
Kokkoris, Stelios
Gratziou, Christina
المصدر
Critical Care Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
Mechanically ventilated patients with left ventricular (LV) dysfunction are at risk of weaning failure.
We hypothesized that optimization of cardiovascular function might facilitate the weaning process.
Therefore, we investigated the efficacy of levosimendan in difficult-to-wean patients with impaired LV performance.
Materials and Methods.
Nineteen mechanically ventilated patients, with LV ejection fraction (LVEF) 34 ± 8%, difficult-to-wean from the ventilator, were assessed by transthoracic echocardiography before the start and at the end of a spontaneous breathing trial (SBT) (first SBT).
Eight patients successfully weaned.
The remaining 11 failed-to-wean patients received a 24-hour infusion of levosimendan, and they were reassessed during a second SBT.
Results.
After levosimendan administration, LVEF increased from 30 ± 10 to 36 ± 3% (p=0.01).
End-SBT peak e′ velocity increased from 7 to 9 cm/s (p=0.02).
E/e′ increased from 10.5 to 12.9 during the first SBT, whereas it remained constant at 10 throughout the second SBT (p=0.01).
During the second SBT, partial pressure of arterial oxygen and central venous oxygen saturation improved, compared to the first one (93 ± 34 vs.
67 ± 28 mmHg, p=0.03, and 66 ± 11% vs.
57 ± 9%, p=0.02, respectively).
Nine of the 11 patients were successfully weaned from the ventilator.
Conclusions.
In difficult-to-wean from mechanical ventilation patients with LV dysfunction, levosimendan might contribute to successful weaning by improving both systolic and diastolic LV function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kaltsi, Ifigeneia& Angelopoulos, Epameinondas& Tzanis, Georgios& Sideris, Antonios& Tyrovolas, Konstantinos& Kokkoris, Stelios…[et al.]. 2019. Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study. Critical Care Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129123
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kaltsi, Ifigeneia…[et al.]. Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study. Critical Care Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1129123
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kaltsi, Ifigeneia& Angelopoulos, Epameinondas& Tzanis, Georgios& Sideris, Antonios& Tyrovolas, Konstantinos& Kokkoris, Stelios…[et al.]. Contribution of Levosimendan in Weaning from Mechanical Ventilation in Patients with Left Ventricular Dysfunction: A Pilot Study. Critical Care Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1129123
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1129123
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر