Antilipoxygenase and Anti-Inflammatory Activities of Streblus asper Leaf Extract on Xylene-Induced Ear Edema in Mice

المؤلفون المشاركون

Singsai, Kanathip
Charoongchit, Pimchanok
Chaikaew, Waritsara
Boonma, Nirut
Fhanjaksai, Pitsinee
Chaisatan, Karitta

المصدر

Advances in Pharmacological and Pharmaceutical Sciences

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-12-07

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

علم الصيدلة

الملخص EN

Streblus asper (SA) belonging to the Moraceae family is well known as a folk medicinal plant in Asian countries.

This study aimed to investigate the antilipoxygenase activity and the anti-inflammatory effects of the SA leaf extract.

An in vitro antilipoxygenase study was performed using a lipoxygenase assay, and the oxidation of linoleic acid into 13-hydroperoxy linoleic acid (HPODE) was detected with a UV spectrophotometer at a wavelength of 234 nm.

In the animal study, twenty-five male ICR mice were induced as ear edema by topical xylene, and the ear thickness of the mice was measured.

The lipoxygenase assay results showed that the IC50 values of diclofenac sodium and SA were 0.0015 and 37.96 μg/mL, respectively.

In the animal study, mice that received diclofenac sodium exhibited significantly reduced ear edema induced by xylene from 30 min onward, while mice that received 250 mg/kg and 500 mg/kg SA exhibited significantly reduced ear edema compared with the control group 45 min after induction with xylene.

These results suggested that the SA leaf extract had anti-inflammatory activity.

However, further studies are required to evaluate these effects and the additional potential of the plant that might be beneficial for the development of pharmaceutical products that prevent and treat inflammation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Singsai, Kanathip& Charoongchit, Pimchanok& Chaikaew, Waritsara& Boonma, Nirut& Fhanjaksai, Pitsinee& Chaisatan, Karitta. 2020. Antilipoxygenase and Anti-Inflammatory Activities of Streblus asper Leaf Extract on Xylene-Induced Ear Edema in Mice. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1130078

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Singsai, Kanathip…[et al.]. Antilipoxygenase and Anti-Inflammatory Activities of Streblus asper Leaf Extract on Xylene-Induced Ear Edema in Mice. Advances in Pharmacological and Pharmaceutical Sciences No. 2020 (2020), pp.1-5.
https://search.emarefa.net/detail/BIM-1130078

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Singsai, Kanathip& Charoongchit, Pimchanok& Chaikaew, Waritsara& Boonma, Nirut& Fhanjaksai, Pitsinee& Chaisatan, Karitta. Antilipoxygenase and Anti-Inflammatory Activities of Streblus asper Leaf Extract on Xylene-Induced Ear Edema in Mice. Advances in Pharmacological and Pharmaceutical Sciences. 2020. Vol. 2020, no. 2020, pp.1-5.
https://search.emarefa.net/detail/BIM-1130078

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1130078