Laparoscopic versus Open Surgery for Hepatocellular Carcinoma: A Meta-Analysis of High-Quality Case-Matched Studies
المؤلفون المشاركون
Chen, Ke
Pan, Yu
Zhang, Bin
Liu, Xiao-long
Maher, Hendi
Zheng, Xue-yong
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-01
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Objective.
To present a meta-analysis of high-quality case-matched studies comparing laparoscopic (LH) and open hepatectomy (OH) for hepatocellular carcinoma (HCC).
Methods.
Studies published up to September 2017 comparing LH and OH for HCC were identified.
Selection of high-quality, nonrandomized comparative studies (NRCTs) with case-matched design was based on a validated tool (Methodological Index for Nonrandomized Studies) since no randomized controlled trials (RCTs) were published.
Morbidity, mortality, operation time, blood loss, hospital stay, margin distance, recurrence, and survival outcomes were compared.
Subgroup analyses were carried out according to the surgical extension (minor or major hepatectomy).
Results.
Twenty studies with a total of 830 patients (388 in LH and 442 in OH) were identified.
For short-term surgical outcomes, LH showed less morbidity (RR = 0.55; 95% CI, 0.47~0.65; P<0.01), less mortality (RR = 0.43; 95% CI, 0.18~1.00; P=0.05), less blood loss (WMD = −93.21 ml, 95% CI, −157.33~−29.09 ml; P<0.01), shorter hospital stay (WMD = −2.86, 95% CI, −3.63~−2.08; P<0.01), and comparable operation time (WMD = 9.15 min; 95% CI: −7.61~25.90, P=0.28).
As to oncological outcomes, 5-year overall survival rate was slightly better in LH than OH (HR = 0.66, 95% CI: 0.52~0.84, P<0.01), whereas the 5-year disease-free survival rate was comparable between two groups (HR = 0.88, 95% CI: 0.74~1.06, P=0.18).
Conclusion.
This meta-analysis has highlighted that LH can be safely performed in selective patients and improves surgical outcomes as compared to OH.
Given the limitations of study design, especially the limited cases of major hepatectomy, methodologically high-quality comparative studies are needed for further evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Ke& Pan, Yu& Zhang, Bin& Liu, Xiao-long& Maher, Hendi& Zheng, Xue-yong. 2018. Laparoscopic versus Open Surgery for Hepatocellular Carcinoma: A Meta-Analysis of High-Quality Case-Matched Studies. Canadian Journal of Gastroenterology and Hepatology،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1130877
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Ke…[et al.]. Laparoscopic versus Open Surgery for Hepatocellular Carcinoma: A Meta-Analysis of High-Quality Case-Matched Studies. Canadian Journal of Gastroenterology and Hepatology No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1130877
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Ke& Pan, Yu& Zhang, Bin& Liu, Xiao-long& Maher, Hendi& Zheng, Xue-yong. Laparoscopic versus Open Surgery for Hepatocellular Carcinoma: A Meta-Analysis of High-Quality Case-Matched Studies. Canadian Journal of Gastroenterology and Hepatology. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1130877
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130877
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر