Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa
المؤلفون المشاركون
Bessong, Pascal O.
Gachara, George
Mavhandu, Lufuno G.
Rogawski, Elizabeth T.
Manhaeve, Cecile
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Optimal adherence to combination antiretroviral therapy (cART) is critical to maintain virologic suppression, thereby ensuring the global success of HIV treatment.
We evaluated adherence to cART using pharmacy refill records and determined the adherence threshold resulting in >90% virologic suppression in a community run treatment site in South Africa.
Additionally, we analysed factors associated with adherence using univariable and multivariable logistic regression models.
Logistic regression was also performed to determine the relationship between adherence and virologic suppression and the adherence threshold resulting in <10% virologic failure.
The overall median (interquartile range) adherence was 95% (88.6–98.4%).
Out of the study participants, 210/401 (52.4%) had optimal (≥95%) adherence while only 37/401 (9.2%) had poor (≤80%) adherence.
The majority (90.5%) of patients with optimal adherence had virologic suppression.
Having TB at registration into care was found to be negatively associated with adherence (adjusted odds ratio [AOR], 0.382; p≤.05).
Compared to nonadherent individuals, optimally adherent participants were more likely to achieve virologic suppression (OR 2.92; 95% CI: 1.63–5.22).
Only adherence rates above 95% were observed to lead to <10% virologic failure.
cART adherence measured by pharmacy refill records could serve as a useful predictor of virologic failure; adherence rates >95% are needed to maintain optimal virologic suppression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gachara, George& Mavhandu, Lufuno G.& Rogawski, Elizabeth T.& Manhaeve, Cecile& Bessong, Pascal O.. 2017. Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa. AIDS Research and Treatment،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1130937
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gachara, George…[et al.]. Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa. AIDS Research and Treatment No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1130937
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gachara, George& Mavhandu, Lufuno G.& Rogawski, Elizabeth T.& Manhaeve, Cecile& Bessong, Pascal O.. Evaluating Adherence to Antiretroviral Therapy Using Pharmacy Refill Records in a Rural Treatment Site in South Africa. AIDS Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1130937
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1130937
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر