The Application of Dynamic Models to the Exploration of β1-AR Overactivation as a Cause of Heart Failure
المؤلفون المشاركون
Liu, Huirong
Wang, Xiaoyun
Zhao, Min
Wang, Xiaoqiang
Cao, Ning
Li, Shuping
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
High titer of β1-adrenoreceptor autoantibodies (β1-AA) has been reported to appear in heart failure patients.
It induces sustained β1-adrenergic receptor (β1-AR) activation which leads to heart failure (HF), but the mechanism is as yet unclear.
In order to investigate the mechanisms causing β1-AR non-desensitization, we studied the beating frequency of the neonatal rat cardiomyocytes (NRCMs) under different conditions (an injection of isoprenaline (ISO) for one group and β1-AA for the other) and established three dynamic models in order to best describe the true relationships shown in medical experiments; one model used a control group of healthy rats; then in HF rats one focused on conformation changes in β1-AR; the other examined interaction between β1-AR and β2-adrenergic receptors (β2-AR).
Comparing the experimental data and corresponding Akaike information criterion (AIC) values, we concluded that the interaction model was the most likely mechanism.
We used mathematical methods to explore the mechanism for the development of heart failure and to find potential targets for prevention and treatment.
The aim of the paper was to provide a strong theoretical basis for the clinical development of personalized treatment programs.
We also carried out sensitivity analysis of the initial concentration β1-AA and found that they had a noticeable effect on the fitting results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiaoyun& Zhao, Min& Wang, Xiaoqiang& Li, Shuping& Cao, Ning& Liu, Huirong. 2018. The Application of Dynamic Models to the Exploration of β1-AR Overactivation as a Cause of Heart Failure. Computational and Mathematical Methods in Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131791
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiaoyun…[et al.]. The Application of Dynamic Models to the Exploration of β1-AR Overactivation as a Cause of Heart Failure. Computational and Mathematical Methods in Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1131791
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiaoyun& Zhao, Min& Wang, Xiaoqiang& Li, Shuping& Cao, Ning& Liu, Huirong. The Application of Dynamic Models to the Exploration of β1-AR Overactivation as a Cause of Heart Failure. Computational and Mathematical Methods in Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1131791
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1131791
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر