Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation
المؤلفون المشاركون
Li, Jian
Lu, Yufan
Li, Ning
Li, Peijun
Wang, Zhengrong
Ting, Wang
Liu, Xiaodan
Wu, Weibing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-07
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature.
Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease.
Abnormal glucose and lipid metabolism are also closely related to inflammation processes.
Further insights into the interactions of inflammation and glucose and lipid metabolism might therefore inspire novel therapeutic interventions to promote lung rehabilitation.
Chemerin, as a recently discovered adipokine, has been shown to play a role in inflammatory response and glucose and lipid metabolism in many diseases (including COPD).
Chemerin recruits inflammatory cells to sites of inflammation during the early stages of COPD, leading to endothelial barrier dysfunction, early vascular remodeling, and angiogenesis.
Moreover, it supports the recruitment of antigen-presenting cells that guide immune cells as part of the body’s inflammatory responses.
Chemerin also regulates metabolism via activation of its cognate receptors.
Glucose homeostasis is affected via effects on insulin secretion and sensitivity, and lipid metabolism is changed by increased transformation of preadipocytes to mature adipocytes through chemerin-binding receptors.
Controlling chemerin signaling may be a promising approach to improve various aspects of COPD-related dysfunction.
Importantly, several studies indicate that chemerin expression in vivo is influenced by exercise.
Although available evidence is still limited, therapeutic alterations of chemerin activity may be a promising target of therapeutic approaches aimed at the rehabilitation of COPD patients based on exercises.
In conclusion, chemerin plays an essential role in COPD, especially in the inflammatory responses and metabolism, and has a potential to become a target for, and a biomarker of, curative mechanisms underlying exercise-mediated lung rehabilitation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jian& Lu, Yufan& Li, Ning& Li, Peijun& Wang, Zhengrong& Ting, Wang…[et al.]. 2020. Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation. BioMed Research International،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1134002
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jian…[et al.]. Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation. BioMed Research International No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1134002
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jian& Lu, Yufan& Li, Ning& Li, Peijun& Wang, Zhengrong& Ting, Wang…[et al.]. Chemerin: A Potential Regulator of Inflammation and Metabolism for Chronic Obstructive Pulmonary Disease and Pulmonary Rehabilitation. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1134002
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134002
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر