Effects of Paeonia lactiflora Extract on Estrogen Receptor β, TPH2, and SERT in Rats with PMS Anxiety

المؤلفون المشاركون

Wei, Sheng
Gao, Dongmei
Song, Chunhong
Qiao, Mingqi
Wang, Jieqiong
Sun, Wenjun
Guo, Yinghui
Sun, Shiguang
Tian, Xi
Li, Huihao

المصدر

BioMed Research International

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-03-07

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

This study is to investigate the effect of Paeonia lactiflora extract on PMS anxiety and on expression of estrogen receptor β (ERβ), tryptophan hydroxylase-2 (TPH2), and serotonin transporter (SERT) in the premenstrual syndrome (PMS) anxiety model rats.

The vaginal smear and open field test were used to screen rats in nonreception phase of estrus cycle with similar macroscopic behaviors and regular estrus cycle.

PMS anxiety model rats were prepared by electrical stimulation.

RT-PCR and immunofluorescence were used to measure the expression of ERβ, TPH2, and SERT.

Compared with normal rats, the total distance in the open field test of the model rats was significantly increased (P<0.05).

The model rats showed nervous alertness, irritability, and sensitivity to external stimuli.

After treatment with the Paeonia lactiflora extract, the total distance of rats was significantly reduced (P<0.05).

In reception stage, there was no significant difference in the mRNA and protein expression of ERβ, TPH2, and SERT.

In nonreception stage, the expression of ERβ and TPH2 in the model group was significantly decreased (P<0.05) as compared with the control group, but not SERT.

Abnormal changes of the above indicators were reversed after the administration of the Paeonia lactiflora extract.

In conclusion, Paeonia lactiflora extract can increase the expression of ERβ and TPH2 and decrease SERT in PMS model rats, which may be one of the mechanisms underlying the effect of Paeonia lactiflora extract on PMS.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Jieqiong& Song, Chunhong& Gao, Dongmei& Wei, Sheng& Sun, Wenjun& Guo, Yinghui…[et al.]. 2020. Effects of Paeonia lactiflora Extract on Estrogen Receptor β, TPH2, and SERT in Rats with PMS Anxiety. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134108

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Jieqiong…[et al.]. Effects of Paeonia lactiflora Extract on Estrogen Receptor β, TPH2, and SERT in Rats with PMS Anxiety. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134108

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Jieqiong& Song, Chunhong& Gao, Dongmei& Wei, Sheng& Sun, Wenjun& Guo, Yinghui…[et al.]. Effects of Paeonia lactiflora Extract on Estrogen Receptor β, TPH2, and SERT in Rats with PMS Anxiety. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134108

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1134108