Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis
المؤلفون المشاركون
Hu, Bangli
Qiu-lan, Huang
Lei, Rong-e
Shi, Cheng
Jiang, Hai-xing
Qin, Shan-yu
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Both IL-9 and miR-200a are involved in the pathogenesis of cancers; however, the role of IL-9 in pancreatic cancer and the possible underlying mechanisms remain unknown.
The aim of this study was to investigate the effect of IL-9 on pancreatic cancer cells and its interaction with miR-200a.
Methods.
Pancreatic cancer cells (PANC-1 and AsPC-1) were treated with IL-9 and the expression of miR-200a and β-catenin in pancreatic cancer cells was measured.
β-Catenin was examined as a target gene of miR-200a in pancreatic cancer cells.
The interaction between IL-9 and miR-200a in pancreatic cancer cells was determined by infecting miR-200a mimics prior to IL-9 treatment and then measuring miR-200a and β-catenin expression.
Results.
IL-9 significantly promoted the proliferation, invasion, and migration of pancreatic cancer cells; however, the effect on pancreatic cancer cell apoptosis was insignificant.
β-Catenin was verified as a target gene of miR-200a in pancreatic cancer cells.
Overexpression of miR-200a in pancreatic cancer cells significantly attenuated proliferation and metastasis and reduced β-catenin expression.
IL-9 treatment of pancreatic cancer cells decreased miR-200a expression and increased β-catenin expression.
The effect of miR-200a on pancreatic cancer cells decreased following IL-9 treatment.
Conclusions.
IL-9 promotes proliferation and metastasis in pancreatic cancer cells; this effect may partly involve regulation of the miR-200a/β-catenin axis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Bangli& Qiu-lan, Huang& Lei, Rong-e& Shi, Cheng& Jiang, Hai-xing& Qin, Shan-yu. 2017. Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135448
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Bangli…[et al.]. Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1135448
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Bangli& Qiu-lan, Huang& Lei, Rong-e& Shi, Cheng& Jiang, Hai-xing& Qin, Shan-yu. Interleukin-9 Promotes Pancreatic Cancer Cells Proliferation and Migration via the miR-200aBeta-Catenin Axis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1135448
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135448
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر