Increased Expression of Myeloid-Derived Suppressor Cells in Patients with HBV-Related Hepatocellular Carcinoma
المؤلفون المشاركون
Li, Tianyu
Zhang, Xinyu
Lv, Zhuo
Gao, Li
Yan, Huimin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-14
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background and Aim.
Myeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in tumor immune escape.
Several studies have investigated the involvement of MDSCs into hepatocellular carcinoma (HCC); however, due to the difference of MDSC phenotype, patient types, and sample source among the studies, the results were inconsistent and controversial.
The present study aimed to confirm the expression and clinical significance of MDSCs in HBV-related HCC patients.
Methods.
The percentages of MDSCs, IFN-γ-producing CD4 and CD8 T cells in the peripheral blood of HCC patients, chronic hepatitis B (CHB) patients, and healthy controls (HC) were determined by flow cytometry.
The serum concentrations of IL-10 and TNF-α were determined by ELISA.
The association of the percentages of MDSCs with tumor burden, liver function parameters, systemic inflammation-related indexes, and IFN-γ-producing T cells was assessed.
Results.
The percentages of MDSCs and PMN-MDSCs were significantly higher in HCC patients than those in CHB patients and HC.
The level of MDSCs was correlated with indirect bilirubin and prealbumin, as well as systemic inflammation response index, monocyte/lymphocyte ratio, and monocyte counts.
The frequency of IFN-γ-producing CD8 T cells of HCC patients was lower than that of HC.
However, there was no relationship between MDSCs and IFN-γ-producing CD8 T cells.
The level of IL-10 in HCC patients was significantly higher than that in CHB patients.
Conclusion.
MDSCs seem to play an important role in the process leading from chronic HBV infection to HCC.
Early inhibiting these cells could affect tumor progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Tianyu& Zhang, Xinyu& Lv, Zhuo& Gao, Li& Yan, Huimin. 2020. Increased Expression of Myeloid-Derived Suppressor Cells in Patients with HBV-Related Hepatocellular Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135972
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Tianyu…[et al.]. Increased Expression of Myeloid-Derived Suppressor Cells in Patients with HBV-Related Hepatocellular Carcinoma. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1135972
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Tianyu& Zhang, Xinyu& Lv, Zhuo& Gao, Li& Yan, Huimin. Increased Expression of Myeloid-Derived Suppressor Cells in Patients with HBV-Related Hepatocellular Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135972
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135972
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر