Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice
المؤلفون المشاركون
Wang, Xinghua
Yang, Yukun
Zhang, Hening
Liu, Ju
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Detailed safety assessment of sodium selenite and bioselenium (bio-Se) was conducted and the results were compared and discussed for the purpose of assessing safety of bio-Se for use in food applications.
In this work, acute toxicity studies, micronucleus test, and sperm aberration study in mice, 30-day feeding test of mice, were conducted to evaluate the toxicity of bio-Se obtained from yeast with different fermentation time (transformative time: one month, three months, and six months), and the results were compared with that of inorganic Se (sodium selenite).
LD50 of sodium selenite was calculated to be 21.17 mg/kg.
LD50 of bio-Se obtained from yeast with different fermentation time was calculated to be 740.2 mg/kg, 915.3 mg/kg, and 1179.0 mg/kg, respectively.
In the genotoxicity test, bio-Se did not show cytotoxicity and genotoxicity of mice while sodium selenite at all dose groups was significantly different from the negative group.
In the 30-day subchronic oral toxicity study, sodium selenite may slow down the growth of the mice and lead to organic damage to some extent.
Bio-Se had facilitated effect towards the body weight of the mice and had no significant effect on the shape and function of the important organs of the mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xinghua& Yang, Yukun& Zhang, Hening& Liu, Ju. 2017. Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136630
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xinghua…[et al.]. Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136630
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xinghua& Yang, Yukun& Zhang, Hening& Liu, Ju. Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136630
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136630
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر