Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice

المؤلفون المشاركون

Wang, Xinghua
Yang, Yukun
Zhang, Hening
Liu, Ju

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-10-30

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Detailed safety assessment of sodium selenite and bioselenium (bio-Se) was conducted and the results were compared and discussed for the purpose of assessing safety of bio-Se for use in food applications.

In this work, acute toxicity studies, micronucleus test, and sperm aberration study in mice, 30-day feeding test of mice, were conducted to evaluate the toxicity of bio-Se obtained from yeast with different fermentation time (transformative time: one month, three months, and six months), and the results were compared with that of inorganic Se (sodium selenite).

LD50 of sodium selenite was calculated to be 21.17 mg/kg.

LD50 of bio-Se obtained from yeast with different fermentation time was calculated to be 740.2 mg/kg, 915.3 mg/kg, and 1179.0 mg/kg, respectively.

In the genotoxicity test, bio-Se did not show cytotoxicity and genotoxicity of mice while sodium selenite at all dose groups was significantly different from the negative group.

In the 30-day subchronic oral toxicity study, sodium selenite may slow down the growth of the mice and lead to organic damage to some extent.

Bio-Se had facilitated effect towards the body weight of the mice and had no significant effect on the shape and function of the important organs of the mice.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Wang, Xinghua& Yang, Yukun& Zhang, Hening& Liu, Ju. 2017. Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136630

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Wang, Xinghua…[et al.]. Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136630

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Wang, Xinghua& Yang, Yukun& Zhang, Hening& Liu, Ju. Safety Assessment and Comparison of Sodium Selenite and Bioselenium Obtained from Yeast in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136630

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1136630