β-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERKp38 and NF-κB Pathways in LPS-Exposed BV2 Cells
المؤلفون المشاركون
Sun, Yanan
Gao, Ling
Hou, Wei
Wu, Jie
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Neurodegenerative disease is a disease state in which neurons in the spinal cord and brain are lost.
Studies show that sustained neuroinflammatory reactions release toxic factors, damage neurons, and lead to neurodegenerative diseases.
Therefore, inhibiting neuroinflammation may be an effective measure to alleviate neurodegenerative diseases.
Microglia is an important participant in the neuroinflammatory response.
β-Sitosterol (BS) is widely found in various vegetable oils, nuts, and other plant seeds.
Studies have found that BS has a wide range of anti-inflammatory effects in peritoneal macrophages and other peripheral tissues.
However, no studies have reported the effect of BS that impacts microglia activity.
Herein, we further study the effect of BS on impacts microglia activity.
Firstly, BV2, a murine microglial cell, was treated with different concentrations of BS prior to stimulation of LPS, and then the inflammatory mediators and the expression of related signaling molecules were tested.
The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-α (TNF-α), and cyclooxygenase-2(COX-2)).
The related signaling pathway analysis demonstrated that BS treatment can inhibit the LPS-induced activation of p38, ERK, and NF-κB pathways.
To sum up, the results demonstrated that BS impacts microglia activity via repressing the activation of p38, ERK, and NF-κB pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Yanan& Gao, Ling& Hou, Wei& Wu, Jie. 2020. β-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERKp38 and NF-κB Pathways in LPS-Exposed BV2 Cells. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1136949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Yanan…[et al.]. β-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERKp38 and NF-κB Pathways in LPS-Exposed BV2 Cells. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1136949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Yanan& Gao, Ling& Hou, Wei& Wu, Jie. β-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERKp38 and NF-κB Pathways in LPS-Exposed BV2 Cells. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1136949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر