Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.

المؤلفون المشاركون

Zou, Zhongmei
Yuan, Chao
Ding, Gang
Wang, Hai-Ying
Guo, Yu-Hua
Shang, Hai
Ma, Xiao-Jun

المصدر

BioMed Research International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-05-16

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Five new polyketide-terpene hybrid metabolites (1–5) with highly functionalized groups, together with six known derivatives (6–11), were isolated from the endolichenic fungus Pestalotiopsis sp.

Their structures were elucidated by extensive NMR experiments including 1H, 13C, HMQC, COSY, and HMBC.

The relative configurations of the new compounds were determined by analysis of coupling constants and ROESY correlations.

The absolute configurations especially the secondary alcohol at C-15 in 1 and secondary alcohol at C-14 in 5 were established via the CD experiments of the in situ formed [Rh2(OCOCF3)4] complex with the acetonide derivatives.

These compounds were tested for their inhibition activity against six plant pathogens.

Compounds 1 and 5 exhibited pronounced efficiency against Fusarium oxysporum, and compounds 5 and 6 potently inhibited Fusarium gramineum with MIC value of 8 µg/mL, which revealed the plausible ecological role of endolichenic fungus in providing chemical protection for its host lichen in the fungus-plant relationship.

The biosynthetic pathway of compounds 1–11 was postulated for the first time, which paved the way for its further biosynthesis research.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Yuan, Chao& Ding, Gang& Wang, Hai-Ying& Guo, Yu-Hua& Shang, Hai& Ma, Xiao-Jun…[et al.]. 2017. Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138314

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Yuan, Chao…[et al.]. Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1138314

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Yuan, Chao& Ding, Gang& Wang, Hai-Ying& Guo, Yu-Hua& Shang, Hai& Ma, Xiao-Jun…[et al.]. Polyketide-Terpene Hybrid Metabolites from an Endolichenic Fungus Pestalotiopsis sp.. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1138314

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1138314