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The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence
المؤلفون المشاركون
Assefa, Brhane Teklebrhan
Wondafrash, Dawit Zewdu
Gidey, Meles Tekie
Tafere, Gebrehiwot Gebremedhin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-18
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Alzheimer’s disease is a multifactorial neurodegenerative disease characterized by progressive cognitive dysfunction.
It is the most common form of dementia.
The pathologic hallmarks of the disease include extracellular amyloid plaque, intracellular neurofibrillary tangles, and oxidative stress, to mention some of them.
Despite remarkable progress in the understanding of the pathogenesis of the disease, drugs for cure or disease-modifying therapy remain somewhere in the distance.
From recent time, the signaling molecule AMPK is gaining enormous attention in the AD drug research.
AMPK is a master regulator of cellular energy metabolism, and recent pieces of evidence show that perturbation of its function is highly ascribed in the pathology of AD.
Several drugs are known to activate AMPK, but their effect in AD remains to be controversial.
In this review, the current shreds of evidence on the effect of AMPK activators in Aβ accumulation, tau aggregation, and oxidative stress are addressed.
Positive and negative effects are reported with regard to Aβ and tauopathy but only positive in oxidative stress.
We also tried to dissect the molecular interplays where the bewildering effects arise from.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Assefa, Brhane Teklebrhan& Tafere, Gebrehiwot Gebremedhin& Wondafrash, Dawit Zewdu& Gidey, Meles Tekie. 2020. The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence. BioMed Research International،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1138349
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Assefa, Brhane Teklebrhan…[et al.]. The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence. BioMed Research International No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1138349
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Assefa, Brhane Teklebrhan& Tafere, Gebrehiwot Gebremedhin& Wondafrash, Dawit Zewdu& Gidey, Meles Tekie. The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1138349
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1138349
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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