Punctaporonins N–S, New Caryophyllene Sesquiterpenoids from Cytospora sp.

الملخص EN

Six new caryophyllene sesquiterpenoids, punctaporonins N–S (1–6), and three known ones, 6-hydroxypunctaporonins B (7), A (8), and E (9), have been isolated from solid cultures of Cytospora sp.

The structures of 1–6 were elucidated primarily by NMR spectroscopy.

The absolute configuration of 1 was assigned by X-ray crystallographic analysis of its S-MTPA ester.

Compounds 2, 5, and 6 showed modest cytotoxicity against HeLa cells.