A Multiscale Model for the World’s First Parasitic Disease Targeted for Eradication: Guinea Worm Disease
المؤلفون المشاركون
Garira, Winston
Netshikweta, Rendani
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-29، 29ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-20
دولة النشر
مصر
عدد الصفحات
29
التخصصات الرئيسية
الملخص EN
Guinea worm disease (GWD) is both a neglected tropical disease and an environmentally driven infectious disease.
Environmentally driven infectious diseases remain one of the biggest health threats for human welfare in developing countries and the threat is increased by the looming danger of climate change.
In this paper we present a multiscale model of GWD that integrates the within-host scale and the between-host scale.
The model is used to concurrently examine the interactions between the three organisms that are implicated in natural cases of GWD transmission, the copepod vector, the human host, and the protozoan worm parasite (Dracunculus medinensis), and identify their epidemiological roles.
The results of the study (through sensitivity analysis of R0) show that the most efficient elimination strategy for GWD at between-host scale is to give highest priority to copepod vector control by killing the copepods in drinking water (the intermediate host) by applying chemical treatments (e.g., temephos, an organophosphate).
This strategy should be complemented by health education to ensure that greater numbers of individuals and communities adopt behavioural practices such as voluntary reporting of GWD cases, prevention of GWD patients from entering drinking water bodies, regular use of water from safe water sources, and, in the absence of such water sources, filtering or boiling water before drinking.
Taking into account the fact that there is no drug or vaccine for GWD (interventions which operate at within-host scale), the results of our study show that the development of a drug that kills female worms at within-host scale would have the highest impact at this scale domain with possible population level benefits that include prevention of morbidity and prevention of transmission.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Netshikweta, Rendani& Garira, Winston. 2017. A Multiscale Model for the World’s First Parasitic Disease Targeted for Eradication: Guinea Worm Disease. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-29.
https://search.emarefa.net/detail/BIM-1141949
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Netshikweta, Rendani& Garira, Winston. A Multiscale Model for the World’s First Parasitic Disease Targeted for Eradication: Guinea Worm Disease. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-29.
https://search.emarefa.net/detail/BIM-1141949
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Netshikweta, Rendani& Garira, Winston. A Multiscale Model for the World’s First Parasitic Disease Targeted for Eradication: Guinea Worm Disease. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-29.
https://search.emarefa.net/detail/BIM-1141949
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1141949
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر