Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome
المؤلفون المشاركون
Subasinghe, Chandrika Jayakanthi
Somasundaram, Noel
Sivatharshya, Pathmanathan
Ranasinghe, Lalana Devi
Korbonits, Márta
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Multiple endocrine neoplasia (MEN) type 1 syndrome is an autosomal dominant disorder caused by germline mutations in MEN1 gene, characterized by tumours in endocrine and nonendocrine organs.
Giant prolactinoma is defined as tumours larger than 40mm with very high prolactin secretion.
We report two unrelated Sri Lankan patients (8-year-old boy and a 20-year-old female) who presented with giant prolactinomas with mass effects of the tumours.
The female patient showed complete response to medical therapy, while the boy developed recurrent resistant prolactinoma needing surgery and radiotherapy.
During follow-up, both developed pancreatic neuroendocrine tumours.
Genetic analysis revealed that one was heterozygous for a nonsense mutation and other for missense mutation in MEN1 gene.
Screening confirmed familial MEN-1 syndrome in their families.
High clinical suspicion upon unusual clinical presentation prompted genetic evaluation in these patients and detection of MEN1 gene mutation.
Pituitary adenomas in children with MEN-1 syndrome are larger tumours with higher rates of treatment resistance.
This report emphasizes importance of screening young patients with giant prolactinoma for MEN-1 syndrome and arranging long-term follow-up for them expecting variable treatment outcomes.
Sri Lanka requires further studies to describe the genotypic-phenotypic variability of MEN-1 syndrome in this population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Subasinghe, Chandrika Jayakanthi& Somasundaram, Noel& Sivatharshya, Pathmanathan& Ranasinghe, Lalana Devi& Korbonits, Márta. 2018. Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome. Case Reports in Endocrinology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1142920
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Subasinghe, Chandrika Jayakanthi…[et al.]. Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome. Case Reports in Endocrinology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1142920
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Subasinghe, Chandrika Jayakanthi& Somasundaram, Noel& Sivatharshya, Pathmanathan& Ranasinghe, Lalana Devi& Korbonits, Márta. Giant Prolactinoma of Young Onset: A Clue to Diagnosis of MEN-1 Syndrome. Case Reports in Endocrinology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1142920
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1142920
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر