Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography
المؤلفون المشاركون
Fedele, Francesco
Mancone, Massimo
Sardella, Gennaro
Maestrini, Viviana
Infusino, Fabio
Calcagno, Simone
Dettori, Olga
Taccheri, Temistocle
Bruno, Pasqualina
المصدر
Cardiology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Residual angina after PCI is a frequently occurring disease.
Ivabradine improves symptoms but its role in patients without left ventricular systolic dysfunction is still unclear.
The aim was to quantify the effects of ivabradine in terms of MVO2 indicators and diastolic function.
Methods.
Twenty-eight consecutive patients with residual angina after PCI were randomized to ivabradine 5 mg twice/day (IG) or standard therapy (CG).
All patients performed a stress echocardiography at the enrollment and after 30 days.
MVO2 was estimated from double product (DP) and triple product (TP) integrating DP with ejection time (ET).
Diastolic function was evaluated determining E and A waves, E′ measurements, and E/E′ ratio both at rest and at the peak of exercise.
Results.
The exercise time was longer in IG 9′49″ ± 48″ vs 8′09″ ± 59″ in CG (p=0.0001), reaching a greater workload (IG 139.3 ± 13.4 vs CG 118.7 ± 19.6 Watts; p=0.003).
MVO2 expressed with DP and TP was significantly higher in IG (DP: IG 24194 ± 2697 vs CG 20358 ± 4671.8, p=0.01; TP: IG 17239 ± 4710 vs CG 12206 ± 4413, p=0.007).
At peak exercise, the ET was diminished in IG than CG.
The analysis of diastolic function after the exercise revealed an increase of E and A waves, without difference in the E/A ratio.
The E′ wave was higher in IG than CG, and in the same group, the differences between baseline and peak exercise were greater (∆E′3.14 ± 0.7 vs 2.4 ± 1.13, p=0.047).
The E/E′ ratio was reduced in patients treated with ivabradine (IG 10.2 ± 2.0 vs CG 7.9 ± 1.6, p=0.002).
Conclusions.
Ivabradine seems to produce a significant improvement of ischemic threshold, chronotropic reserve, and diastolic function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calcagno, Simone& Infusino, Fabio& Dettori, Olga& Taccheri, Temistocle& Bruno, Pasqualina& Maestrini, Viviana…[et al.]. 2019. Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography. Cardiology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146127
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calcagno, Simone…[et al.]. Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography. Cardiology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1146127
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calcagno, Simone& Infusino, Fabio& Dettori, Olga& Taccheri, Temistocle& Bruno, Pasqualina& Maestrini, Viviana…[et al.]. Effects of Ivabradine on Residual Myocardial Ischemia after PCI Evaluated by Stress Echocardiography. Cardiology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1146127
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1146127
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر