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HER2, NF-κB, and SATB1 Expression Patterns in Gastric Cancer and Their Correlation with Clinical and Pathological Parameters
المؤلفون المشاركون
Grzanka, Dariusz
Smolińska, Marta
Antosik, Paulina
Kasperska, Anna
Neska-Długosz, Izabela
Jóźwicki, Jakub
Klimaszewska-Wiśniewska, Anna
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-14
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Gastric cancer (GC) is currently recognized as one of the most common and fatal tumor worldwide.
The identification of novel biomarkers in relation to clinical information as well as extending the knowledge on a multiple crosstalk between various oncogenic pathways implicated in GC carcinogenesis seems pivotal to limit the disease-associated mortality.
Therefore, we assessed the expression of HER2, NF-κB, and SATB1 in a total of 104 gastric adenocarcinomas and 30 normal gastric samples and correlated the expression patterns with each other and with some clinicopathological variables.
Protein expression was examined by immunohistochemistry (IHC) on tissue microarrays (TMAs), and fluorescence in situ hybridization (FISH) was employed to detect HER2 amplification.
In the studied group, HER2 and SATB1 were found to be overexpressed in gastric cancer tissue in comparison to normal gastric mucosa.
The expression status of the former protein was seen to differ according to some clinicopathological features, but without statistical significance, whereas the expression of the latter was not importantly associated with any of them.
In turn, the NF-κB protein level was significantly related to the presence of lymph node metastasis.
HER2 expression was not significantly correlated with that of other proteins, but a positive correlation was found between the expression of SATB1 and NF-κB.
Further studies with a larger group of patients combined with in vitro mechanistic experiments are required to fully elucidate the role and relationship of HER2, NF-κB, and SATB1 expression in gastric cancer progression.
However, to the best of our knowledge, this study is the first look at a simultaneous evaluation of these three markers in the samples of gastric cancer patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smolińska, Marta& Grzanka, Dariusz& Antosik, Paulina& Kasperska, Anna& Neska-Długosz, Izabela& Jóźwicki, Jakub…[et al.]. 2019. HER2, NF-κB, and SATB1 Expression Patterns in Gastric Cancer and Their Correlation with Clinical and Pathological Parameters. Disease Markers،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smolińska, Marta…[et al.]. HER2, NF-κB, and SATB1 Expression Patterns in Gastric Cancer and Their Correlation with Clinical and Pathological Parameters. Disease Markers No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1147571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smolińska, Marta& Grzanka, Dariusz& Antosik, Paulina& Kasperska, Anna& Neska-Długosz, Izabela& Jóźwicki, Jakub…[et al.]. HER2, NF-κB, and SATB1 Expression Patterns in Gastric Cancer and Their Correlation with Clinical and Pathological Parameters. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1147571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1147571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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