Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration

المؤلفون المشاركون

Vilkeviciute, Alvita
Liutkeviciene, Rasa
Kriauciuniene, Loresa
Gedvilaite, Greta
Kaikaryte, Kriste

المصدر

Disease Markers

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-09-08

دولة النشر

مصر

عدد الصفحات

11

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

To determine the impact of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population.

Methods.

A total of 916 subjects were examined: 309 patients with early AMD, 301 patients with exudative AMD, and 306 healthy controls.

The genotyping of HTRA1 rs11200638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 was carried out using the RT-PCR method.

Results.

Our study showed that single-nucleotide polymorphisms rs3793784 and rs11200638 were associated with increased odds of early and exudative AMD, and the variant in KCTD10 (rs56209061) was found to be associated with decreased odds of early and exudative AMD development after adjustments for age and gender in early AMD analysis and after adjustments only for age in exudative AMD.

The haplotype containing two minor alleles C-A and the G-A haplotype in rs3793784-rs11200638 were statistically significantly associated with an increased risk of exudative AMD development after adjustment for age, while the G-G haplotype showed a protective role against early and exudative AMD and the haplotype C-G in rs3793784-rs11200638 was associated with a decreased risk only of exudative AMD development.

Conclusions.

Our study identified two markers, rs11200638 and rs3793784, as risk factors for early and exudative AMD, and one marker, rs56209061, as a protective factor for early and exudative AMD development.

The haplotypes constructed of rs3793784-rs11200638 were found to be associated with AMD development, as well.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liutkeviciene, Rasa& Vilkeviciute, Alvita& Gedvilaite, Greta& Kaikaryte, Kriste& Kriauciuniene, Loresa. 2019. Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration. Disease Markers،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148042

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liutkeviciene, Rasa…[et al.]. Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration. Disease Markers No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1148042

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liutkeviciene, Rasa& Vilkeviciute, Alvita& Gedvilaite, Greta& Kaikaryte, Kriste& Kriauciuniene, Loresa. Haplotypes of HTRA1 rs1120638, TIMP3 rs9621532, VEGFA rs833068, CFI rs10033900, ERCC6 rs3793784, and KCTD10 rs56209061 Gene Polymorphisms in Age-Related Macular Degeneration. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1148042

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1148042