Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome
المؤلفون المشاركون
Till, Holger
Castellani, Christoph
Kashofer, Karl
Singer, G.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Approximately 40% of children with Hirschsprung’s disease (HD) suffer from Hirschsprung’s associated enterocolitis (HAEC) despite correct surgery.
Disturbances of the intestinal microbiome may play a role.
Treatment with probiotics based on individual analyses of the fecal microbiome has not been published for HD patients with recurrent HAEC yet.
A boy with trisomy 21 received transanal pull-through at the age of 6 months for rectosigmoid HD.
With four years, he suffered from recurrent episodes of HAEC.
The fecal microbiome was measured during three healthy and three HAEC episodes by next-generation sequencing.
The patient was started on daily probiotics for 3 months; the fecal microbiome was measured weekly.
The fecal microbiome differed significantly between healthy and HAEC episodes.
HAEC episodes were associated with significant decreases of Actinobacteria and significant increases of Bacteroidetes and Proteobacteria.
Probiotic treatment led to a significant increase of alpha diversity and a significant increase of Bifidobacterium and Streptococcus as well as decreases of Rikenellaceae, Pseudobutyrivibrio, Blautia, and Lachnospiraceae.
A longitudinal observation of the microbiome has never been performed following correction of Hirschsprung’s disease.
Probiotic treatment significantly changed the fecal microbiome; the alterations were not limited to strains contained in the administered probiotics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singer, G.& Kashofer, Karl& Castellani, Christoph& Till, Holger. 2018. Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome. Case Reports in Pediatrics،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1149041
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singer, G.…[et al.]. Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome. Case Reports in Pediatrics No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1149041
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singer, G.& Kashofer, Karl& Castellani, Christoph& Till, Holger. Hirschsprung’s Associated Enterocolitis (HAEC) Personalized Treatment with Probiotics Based on Gene Sequencing Analysis of the Fecal Microbiome. Case Reports in Pediatrics. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1149041
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1149041
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر