Anti‐Aging Effects of Schisandrae chinensis Fructus Extract: Improvement of Insulin Sensitivity and Muscle Function in Aged Mice
المؤلفون المشاركون
Hur, Haeng Jeon
Kim, Myung-Sunny
Choi, Hojung
Yeon, Myeonghoon
Oh, Byung-Chul
Seo, Eunhui
Jun, Hee-Sook
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Schisandrae chinensis Fructus has a long history of medicinal use as a tonic, a sedative, and an antitussive drug.
In this study, we investigated the beneficial effects of Schisandrae chinensis Fructus ethanol extract (SFe) on metabolism in an aged mouse model.
Sixteen-month-old C57BL/6J mice were fed with a diet supplemented with SFe for 4 months.
Insulin sensitivity was lower at 20 months of age than at 16 months of age; however, the decrease in insulin sensitivity was less in SFe-fed mice.
SFe supplementation also appeared to improve glucose tolerance.
Body weight gain was lower in SFe-fed mice than in mice fed the control diet.
Body fat mass was lower and the lean mass was higher in SFe-fed mice.
In addition, the grip strength was enhanced in SFe-fed mice.
Histological analysis of the tibialis anterior muscle showed that the size of myofiber and slow-twitch red muscle was increased by SFe supplementation.
The expression of proteins related to muscle protein synthesis such as phospho-Erk1 and phospho-S6K1 was increased by SFe supplementation.
The mRNA expression of genes related to myogenesis and their encoded proteins such as MyoD, Myf5, MRF4, myogenin, and myosin heavy chain, was increased, whereas that of genes related to muscle degradation, such as atrogin-1, MuRF-1, and myostatin, were decreased relative to control mice.
These results suggest that SFe supplementation might have beneficial effects for the improvement of insulin sensitivity and inhibition of muscle loss that occur with aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Choi, Hojung& Seo, Eunhui& Yeon, Myeonghoon& Kim, Myung-Sunny& Hur, Haeng Jeon& Oh, Byung-Chul…[et al.]. 2019. Anti‐Aging Effects of Schisandrae chinensis Fructus Extract: Improvement of Insulin Sensitivity and Muscle Function in Aged Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1150177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Choi, Hojung…[et al.]. Anti‐Aging Effects of Schisandrae chinensis Fructus Extract: Improvement of Insulin Sensitivity and Muscle Function in Aged Mice. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1150177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Choi, Hojung& Seo, Eunhui& Yeon, Myeonghoon& Kim, Myung-Sunny& Hur, Haeng Jeon& Oh, Byung-Chul…[et al.]. Anti‐Aging Effects of Schisandrae chinensis Fructus Extract: Improvement of Insulin Sensitivity and Muscle Function in Aged Mice. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1150177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر