Effect of Kangxianling Decoction on Expression of TGF-β1Smads and Extracellular Matrix Deposition
المؤلفون المشاركون
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-01-01
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Kangxianling (KXL) decoction is a traditional Chinese herbal formulation which has been used to treat early and midterm chronic renal failure.
Renal fibrosis is a common characteristic of progressive chronic kidney diseases (CKD).
The formation of renal fibrosis is caused by kidney trauma, infection, and immune response.
The pathophysiological mechanism of renal fibrosis was mainly due to increased collagen synthesis in the kidney, decreased degradation, and a large amount of extracellular matrix (ECM) deposition.
The purpose of this study was intended to evaluate the effect of Kangxianling decoction on expression of TGF-β1/Smad signaling pathway in renal fibrosis rats.
50 specific pathogen-free Sprague Dawley (SPF SD) rats were randomly divided into five groups: control group, sham group, 5/6 nephrectomy model group, 5/6 nephrectomy model plus KXL decoction (21g /kg) group, and 5/6 nephrectomy model plus Losartan Potassium (LP) (33.3 g/kg) group.
The rats were all sacrificed after two months and the left kidney tissue was sampled.
HE staining was used to observe the renal pathological changes and the score of kidney damage was made.
Masson staining was used to observe the degree of renal fibrosis.
Immunohistochemical staining, western blot, and qRT-PCR were used to detect the expression levels of related molecules in TGF-β1/Smad signaling pathway.
The results suggested that KXL could lighten renal histopathology damage, downregulate the expression of TGF-β1 (transforming growth factor-β1), Smad2/3, CTGF (connective tissue growth factor), Collagen I, and Collagen III, and upregulate the expression level of Smad7.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ji, Jing& He, Li Qun. 2019. Effect of Kangxianling Decoction on Expression of TGF-β1Smads and Extracellular Matrix Deposition. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150251
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ji, Jing& He, Li Qun. Effect of Kangxianling Decoction on Expression of TGF-β1Smads and Extracellular Matrix Deposition. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1150251
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ji, Jing& He, Li Qun. Effect of Kangxianling Decoction on Expression of TGF-β1Smads and Extracellular Matrix Deposition. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1150251
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1150251
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر