6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK12-NF-κB Pathway
المؤلفون المشاركون
Xin, Hailiang
Jiang, Yiping
Zhang, Weiyue
Liu, Xiaoyan
Wang, Nani
Li, Feng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Myocardial ischemia/reperfusion (I/R) injury is a key factor in deterioration of myocardial function.
The c-Jun NH2-terminal kinase (JNK) activation and the transcription factor nuclear factor-kappaB (NF-κB) nuclear translocation have been found in I/R injury.
6-Gingerol, an important bioactive ingredient of ginger, has been reported to have cardiovascular pharmacological effects.
However, the molecular mechanism through which it is beneficial is unclear.
In this work, I/R induced the increase in the apoptosis and reactive oxygen species level in AC16 cardiomyocytes.
6-Gingerol administration decreased cardiomyocyte apoptosis and improved oxidative stress indexes.
6-Gingerol administration also inhibited I/R-induced HMGB2 expression upregulation and JNK activation and reduced Cleaved Poly(ADP-ribose) polymerases (PARP) and Caspase-3 expression.
HMGB2 treatment mimicked the effect of I/R-induced cell damage, which was reversed by 6-gingerol administration.
On the other hand, transcriptional activity of NF-κB was reduced in 6-gingerol treated cells.
Thus, overall results indicated that 6-gingerol administration protected I/R-induced cardiomyocytes apoptosis via JNK/NF-κB pathway in the regulation of HMGB2.
This work supported the efficacy of 6-gingerol on cardiovascular disease and partially revealed its mechanism, which was helpful for understanding the therapeutic effects of this natural drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Weiyue& Liu, Xiaoyan& Jiang, Yiping& Wang, Nani& Li, Feng& Xin, Hailiang. 2019. 6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK12-NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Weiyue…[et al.]. 6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK12-NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1151463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Weiyue& Liu, Xiaoyan& Jiang, Yiping& Wang, Nani& Li, Feng& Xin, Hailiang. 6-Gingerol Attenuates Ischemia-Reperfusion-Induced Cell Apoptosis in Human AC16 Cardiomyocytes through HMGB2-JNK12-NF-κB Pathway. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1151463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1151463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر