A Matrix Metalloproteinase-1 Polymorphism, MMP1–1607 (1G>2G)‎, Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients

المؤلفون المشاركون

Wang, Fang-Ming
Zhou, Zhonghan
Zhang, Guiming
Sun, Lijiang
Ma, Xiaocheng

المصدر

Disease Markers

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-12-02

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الأمراض

الملخص EN

Although the matrix metalloproteinase-1 (MMP1) polymorphism MMP1–1607 (1G>2G) has been associated with susceptibility to various cancers, these findings are controversial.

Therefore, we conducted this meta-analysis to explore the association between MMP1–1607 (1G>2G) and cancer risk.

A systematic search of literature through PubMed, Embase, ISI Web of Knowledge, and Google Scholar yielded 77 articles with 21,327 cancer patients and 23,245 controls.

The association between the MMP1–1607 (1G>2G) polymorphism and cancer risks was detected in an allele model (2G vs.

1G, overall risk [OR]: 1.174, 95% confidence interval [CI]: 1.107–1.244), a dominant model (2G2G/1G2G vs.

1G1G OR, OR: 1.192, 95% CI: 1.090–1.303), and a recessive model (2G2G vs.

1G2G/1G1G, OR: 1.231, 95% CI: 1.141–1.329).

In subgroup analysis, these associations were detected in both Asians and Caucasians.

After stratification by cancer types, associations were found in lung, colorectal, nervous system, renal, bladder, and nasopharyngeal cancers.

This meta-analysis revealed that MMP1–1607 (1G>2G) polymorphism was significantly associated with elevated risk of cancers.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhou, Zhonghan& Ma, Xiaocheng& Wang, Fang-Ming& Sun, Lijiang& Zhang, Guiming. 2018. A Matrix Metalloproteinase-1 Polymorphism, MMP1–1607 (1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients. Disease Markers،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1153655

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhou, Zhonghan…[et al.]. A Matrix Metalloproteinase-1 Polymorphism, MMP1–1607 (1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients. Disease Markers No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1153655

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhou, Zhonghan& Ma, Xiaocheng& Wang, Fang-Ming& Sun, Lijiang& Zhang, Guiming. A Matrix Metalloproteinase-1 Polymorphism, MMP1–1607 (1G>2G), Is Associated with Increased Cancer Risk: A Meta-Analysis Including 21,327 Patients. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1153655

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1153655