Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis
المؤلفون المشاركون
Ke, Qiao
Cao, Yingping
Lin, Nanping
Li, Jingrong
Wang, Lei
Liu, Jingfeng
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
To evaluate the prognostic significance of C-reactive protein to albumin ratio (CAR) for clinical outcomes in hepatocellular carcinoma (HCC) patients.
Material and Methods.
Eligible studies were searched by PubMed, MedLine, the Cochrane Library, from January 1, 2000, to June 30, 2019, investigating the prognostic value of CAR in patients with HCC.
Primary endpoint was OS.
Hazard ratio (HR) with 95% confidence interval (CI) was used to determine the effect size.
Results.
7 records including 2208 patients published since 2014 were enrolled into our meta-analysis.
Clinicopathological characteristics were also correlated with the level of CAR.
The pooled HR for the OS rate between low and high CAR groups was 2.13 (95% CI 1.70~2.68, P<0.00001) using a random model, but sensitivity analysis showed that the pooled HR for the OS rates did not change substantially after removal of any included study.
As for patients receiving surgery, the pooled HR for the OS rate between low and high CAR groups was 2.04 (95% CI 1.59~2.61, P<0.00001).
Subgroup analysis showed that CAR could be a prognostic biomarker for HCC patients regardless of regions (China, HR=1.75, 95% CI 1.51~2.02; Japan, HR=3.36, 95% CI 2.07~5.45; Korea, HR=2.26, 95% CI 1.47~4.47; respectively), the cut-off value (<0.1, HR=2.84, 95% CI 1.90~4.24; >0.1, HR=1.99, 95% CI 1.52~2.61; respectively), and sample size (<200, HR=2.85, 95% CI 2.01~4.03; >200, HR=1.75, 95% CI 1.52~2.02; respectively).
Conclusion.
With the current data, we clearly concluded that CAR was closely correlated with prognosis of patients with HCC.
Multicenter, prospective randomized trials are warranted to confirm the conclusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Nanping& Li, Jingrong& Ke, Qiao& Wang, Lei& Cao, Yingping& Liu, Jingfeng. 2020. Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153863
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Nanping…[et al.]. Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1153863
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Nanping& Li, Jingrong& Ke, Qiao& Wang, Lei& Cao, Yingping& Liu, Jingfeng. Clinical Significance of C-Reactive Protein to Albumin Ratio in Patients with Hepatocellular Carcinoma: A Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1153863
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153863
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر