Serum TNF-α Level Is Associated with Disease Severity in Adult Patients with Immunoglobulin A Vasculitis Nephritis
المؤلفون المشاركون
Wu, Haiting
Wen, Yubing
Yue, Cai
Li, Xuemei
Gao, Ruitong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Tumor necrosis factor-α (TNF-α) is a proinflammatory factor involved in the pathogenesis of immunoglobulin A vasculitis (IgAV).
The association between serum TNF-α and disease severity in adult patients with IgAV nephritis (IgAV-N) has been inadequately evaluated.
Methods.
Serum TNF-α was measured by chemiluminescence immunoassay in 53 renal biopsy-proved IgAV-N patients, 53 healthy controls, and 53 IgA nephropathy (IgAN) patients.
The correlations of clinicopathologic parameters of IgAV-N patients with serum TNF-α were analyzed.
Results.
In this cross-sectional study, the median age of IgAV-N patients was 29 (25-37) years, and 67.9% were female.
Serum TNF-α was significantly higher in the IgAV-N group than in the healthy group [7.4 (5.7-9.4) pg/mL vs.
5.9 (5.0, 7.1) pg/mL, P=0.001], but comparable with sex, age, and estimated glomerular filtration rate (eGFR) grade-matched IgAN patients.
Serum creatinine (P=0.006) and serum cystatin C (P=0.001) were positively correlated with serum TNF-α level, while albumin (P=0.014) and eGFR (P=0.021) were negatively correlated with serum TNF-α level.
Multivariate linear regression analysis revealed that eGFR (P=0.007) was an independent clinical predictor of serum TNF-α.
Patients with higher pathological classification grade also had higher serum TNF-α.
Conclusions.
Serum TNF-α is associated with renal function and the pathological classification of adult patients with IgAV-N.
TNF-α is a potential biomarker for the assessment of IgAV-N severity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Haiting& Wen, Yubing& Yue, Cai& Li, Xuemei& Gao, Ruitong. 2020. Serum TNF-α Level Is Associated with Disease Severity in Adult Patients with Immunoglobulin A Vasculitis Nephritis. Disease Markers،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153899
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Haiting…[et al.]. Serum TNF-α Level Is Associated with Disease Severity in Adult Patients with Immunoglobulin A Vasculitis Nephritis. Disease Markers No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1153899
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Haiting& Wen, Yubing& Yue, Cai& Li, Xuemei& Gao, Ruitong. Serum TNF-α Level Is Associated with Disease Severity in Adult Patients with Immunoglobulin A Vasculitis Nephritis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153899
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1153899
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر