Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts
المؤلفون المشاركون
Mampuru, Leseilane
Mokgotho, Matlou Phineas
Bagla, V. P.
Beseni, Brian K.
Njanje, Idris
Matsebatlela, Thabe M.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Diabetes is a severely debilitating metabolic disorder characterised by chronic hyperglycaemia.
Traditional medicinal plants provide an important avenue for the development of novel antidiabetic agents.
The antidiabetic potential of the methanol, acetone, and hexane extracts of S.
plumosum was assessed using different parameters.
These included secondary metabolite quantification, hypoglycaemic, cytotoxic effects, and GLUT4 translocation augmentation on C2C12 cells.
The methanol extract contained the highest amount of total phenolic and flavonoid compounds and showed enhanced antioxidant activity.
The methanol extracts had the best DPPH scavenging (EC50 = 0.72 mg/ml) and ferric reducing powers (EC50 = 2.31 mg/ml).
The hexane extract resulted in the highest glucose uptake activity of 35, 77% with respect to all other treatments after a 6-hour exposure period.
Immunocytochemistry technique further revealed that the increased glucose utilisation may be due to increased membrane fused GLUT4 molecules in C2C12 cells.
The hexane extract was also shown to upregulate the phosphorylation of p70 S6 kinase and Akt1/2.
The study highlights a probable insulin-mimetic activity of the hexane extract via the augmentation of Akt1/2 phosphorylation which is involved in the GLUT4 translocation pathway.
Furthermore, the study represents the first report on the cytotoxic effect, GLUT4 translocation, and glucose uptake potential of S.
plumosum.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Beseni, Brian K.& Bagla, V. P.& Njanje, Idris& Matsebatlela, Thabe M.& Mampuru, Leseilane& Mokgotho, Matlou Phineas. 2017. Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154336
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Beseni, Brian K.…[et al.]. Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1154336
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Beseni, Brian K.& Bagla, V. P.& Njanje, Idris& Matsebatlela, Thabe M.& Mampuru, Leseilane& Mokgotho, Matlou Phineas. Antioxidant, Antiglycation, and Hypoglycaemic Effect of Seriphium plumosum Crude Plant Extracts. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1154336
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154336
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر