Effect of Gelsemium elegans and Mussaenda pubescens, the Components of a Detoxification Herbal Formula, on Disturbance of the Intestinal Absorptions of Indole Alkaloids in Caco-2 Cells
المؤلفون المشاركون
Wang, Yinghao
Wang, Heshan
Wu, Shuisheng
Li, Desen
Chen, Sainan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Gelsemium elegans (GE) is a kind of well-known toxic plant.
It can be detoxified by Mussaenda pubescens (MP), but the detoxification mechanism is still unclear.
Thus, a detoxification herbal formula (GM) comprising GE and MP was derived.
The Caco-2 cells monolayer model was used to evaluate GM effects on transporting six kinds of indole alkaloids of GE.
The bidirectional transport studies demonstrated that absorbance percentage of indole alkaloids in GE increased linearly over time.
But in GM, Papp (AP→BL) values of the most toxic members, gelsenicine, humantenidine, and gelsevirine, were lower than that of Papp (BL→AP) (P<0.05).
The prominent analgesic effect members, gelsemine and koumine, were approximately 1.00 in γ values.
Nowhere was this increasing efflux more pronounced than in the case of indole alkaloids with N-O structure.
In the presence of verapamil, the γ values of humantenidine, gelsenicine, gelsevirine, and humantenine were decreased by 43.69, 41.42, 36.00, and 8.90 percent, respectively.
The γ values in presence of ciclosporin were homologous with a decrease of 42.32, 40.59, 34.00, and 15.07 percent.
It suggested that the efflux transport was affected by transporters.
Taken together, due to the efflux transporters participation, the increasing efflux of indole alkaloids from GM was found in Caco-2 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Yinghao& Wang, Heshan& Wu, Shuisheng& Li, Desen& Chen, Sainan. 2017. Effect of Gelsemium elegans and Mussaenda pubescens, the Components of a Detoxification Herbal Formula, on Disturbance of the Intestinal Absorptions of Indole Alkaloids in Caco-2 Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154418
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Yinghao…[et al.]. Effect of Gelsemium elegans and Mussaenda pubescens, the Components of a Detoxification Herbal Formula, on Disturbance of the Intestinal Absorptions of Indole Alkaloids in Caco-2 Cells. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1154418
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Yinghao& Wang, Heshan& Wu, Shuisheng& Li, Desen& Chen, Sainan. Effect of Gelsemium elegans and Mussaenda pubescens, the Components of a Detoxification Herbal Formula, on Disturbance of the Intestinal Absorptions of Indole Alkaloids in Caco-2 Cells. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1154418
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154418
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر