Tripterygium Glycosides Combined with Leflunomide for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Peng, Qinghua
Yang, Yi Jing
Deng, Ying
Liao, Lin-Li
Peng, Jun
Qin, Yu-Hui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
To undertake an overview on the overall effects of Tripterygium glycosides (TG) combined with Leflunomide (LEF) for rheumatoid arthritis (RA).
Methods.
We searched electronic databases from database establishment time to December 1, 2019.
The clinical trial data of TG combined with LEF (trial group) and control group in the treatment of RA were collected.
The Cochrane system was used to evaluate the quality of the literature.
RevMan 5.3 software was used to conduct a meta-analysis of the eligible studies.
Results.
A total of 12 randomized controlled trials (RCTs) involving 834 patients with RA were included in this study.
The meta-analysis results showed that morning stiffness (mean difference (MD) = −0.29, 95% confidential interval (CI) (−0.45, −0.12), P=0.0005), tender joint count (MD = −1.51, 95% CI (−2.20, −0.83), P=0.0001), swollen joint count (MD = -1.24, 95% CI (−1.59, −0.88), P=0.0001), erythrocyte sedimentation rate (MD = −7.26, 95% CI (−9.92, −4.61), P=0.0001), C-reactive protein (MD = −4.04, 95% CI (−4.93, −3.14), P=0.0001), and rheumatoid factor (MD = −50.88, 95% CI (−72.30, −29.45), P = 0.0001) in the trial groups were lower than those in the control groups.
The total effective rate in the trial group was better than that in the control group (risk ratio (RR) = 1.20, 95% CI (1.13, 1.28), P=0.00001).
However, there was no significant difference of adverse events (RR = 0.83, 95% CI (0.61, 1.13), P=0.23) while comparing the trial groups with the control groups.
Conclusion.
Our results were found to be superior but limited evidence on the effectiveness of TG combined with LEF in the treatment of RA is available.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Yi Jing& Deng, Ying& Liao, Lin-Li& Peng, Jun& Peng, Qinghua& Qin, Yu-Hui. 2020. Tripterygium Glycosides Combined with Leflunomide for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154748
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Yi Jing…[et al.]. Tripterygium Glycosides Combined with Leflunomide for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1154748
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Yi Jing& Deng, Ying& Liao, Lin-Li& Peng, Jun& Peng, Qinghua& Qin, Yu-Hui. Tripterygium Glycosides Combined with Leflunomide for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1154748
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154748
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر