Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling
المؤلفون المشاركون
Tang, Yong-Jun
Huang, Wei-Hua
Song, Qianqian
Zheng, Xiangrong
He, Ruohui
Liu, Jie
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Asthma is a chronic inflammatory disease of the airways, with complex signaling pathways involved in its pathogenesis.
It was reported that paeonol attenuated airway inflammation of ovalbumin (OVA)-induced mice.
Therefore, it is of importance to further investigate the underlying mechanism.
BALB/c mice were challenged with OVA for the asthma model, which was validated by the changed levels of IL-4, IFN-γ, and IgE.
The elevation of IL-4 and the decreasing of IFN-γ were significantly in middle (p<0.05) or high (p<0.01) paeonol dose groups compared with OVA group.
MIP-1β in bronchoalveolar lavage fluid (BALF) also decreased significantly in middle and high paeonol group compared with OVA group (p<0.01), which is similar to the change of its mRNA in lung tissues.
Moreover, the inflammatory cells infiltration and collagen deposition were attenuated by paeonol and montelukast sodium via histology examination.
At last the immune blot of the protein extracted from lung tissues demonstrated that paeonol decreased the expression of TLR4 and the nuclear translocation of NF-κB, as well as the phosphorylation levels of P38 and ERK in asthma model.
In conclusion, paeonol ameliorated OVA-induced asthma through the TLR4/NF-κB and mitogen-activated protein kinase (MAPK) signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Yong-Jun& Huang, Wei-Hua& Song, Qianqian& Zheng, Xiangrong& He, Ruohui& Liu, Jie. 2018. Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Yong-Jun…[et al.]. Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Yong-Jun& Huang, Wei-Hua& Song, Qianqian& Zheng, Xiangrong& He, Ruohui& Liu, Jie. Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4NF-κB and MAPK Signaling. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر