Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice
المؤلفون المشاركون
Choi, Byung Tae
Baek, Jin Ung
Kim, Yu Ri
Kwon, Min Young
Pak, Malk Eun
Park, So Hyun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
From text mining of Dongeuibogam, the 7 herbs in Palmultang can be considered effective candidates for memory enhancement.
We sought to determine whether Gagam-Palmultang, comprising these 7 herbs, ameliorates scopolamine-induced memory impairment in mice, by focusing on the central cholinergic system and memory-related signaling molecules.
Behavioral tests were performed after inducing memory impairment by scopolamine administration.
The cholinergic system activity and memory-related molecules were examined in the hippocampus by enzyme-linked immunosorbent, western blot, and immunofluorescence assays.
Gagam-Palmultang ameliorated scopolamine-induced memory impairment in the Morris water maze test, producing a significant improvement in the mean time required to find the hidden platform.
Treatment with Gagam-Palmultang reduced acetylcholinesterase activity and expression in the hippocampus induced by scopolamine.
The diminished phosphorylated phosphatidylinositide 3-kinase (PI3K), extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB), and mature brain-derived neurotrophic factor (mBDNF) expressions caused by scopolamine administration were attenuated by treatment with Gagam-Palmultang.
This treatment also promoted neuronal cell proliferation in the hippocampus.
Gagam-Palmultang has beneficial effects against scopolamine-induced memory impairments, which are exerted via modulation of the cholinergic system as well as the PI3K and ERK/CREB/BDNF signaling pathway.
Therefore, this multiherb formula may be a useful therapeutic agent for diseases associated with memory impairments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Yu Ri& Kwon, Min Young& Pak, Malk Eun& Park, So Hyun& Baek, Jin Ung& Choi, Byung Tae. 2018. Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154872
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Yu Ri…[et al.]. Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154872
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Yu Ri& Kwon, Min Young& Pak, Malk Eun& Park, So Hyun& Baek, Jin Ung& Choi, Byung Tae. Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154872
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154872
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر