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Protective Effect of Yang Mi Ryung® Extract on Noise-Induced Hearing Loss in Mice
المؤلفون المشاركون
Kim, Min Soo
Kwak, SeongAe
Baek, Heumyoung
Li, Zewu
Choe, Seong-Kyu
Song, Kyung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Noise-induced hearing loss (NIHL) results from the damage of the delicate hair cells inside the ear after excessive stimulation of noise.
Unlike certain lower animals such as amphibians, fishes, and birds, in humans, hair cells cannot be regenerated once they are killed or damaged; thus, there are no therapeutic options to cure NIHL.
Therefore, it is more important to protect hair cells from the noise before the damage occurs.
In this study, we report the protective effect of Yang Mi Ryung extract (YMRE) against NIHL; this novel therapeutic property of YMRE has not been reported previously.
Our data demonstrates that the hearing ability damaged by noise is markedly restored in mice preadministrated with YMRE before noise exposure, to the level of normal control group.
Our study also provides the molecular mechanism underlying the protective effect of YMRE against NIHL by showing that YMRE significantly blocks noise-induced apoptotic cell death and reduces reactive oxygen species (ROS) production in cochleae.
Moreover, quantitative polymerase chain reaction (qPCR) analysis demonstrates that YMRE has anti-inflammatory properties, suppressing the mRNA levels of TNFα and IL-1β induced by noise exposure.
In conclusion, YMRE could be a useful preventive intervention to prevent hearing impairment induced by the exposure to excessive noise.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, Min Soo& Kwak, SeongAe& Baek, Heumyoung& Li, Zewu& Choe, Seong-Kyu& Song, Kyung. 2017. Protective Effect of Yang Mi Ryung® Extract on Noise-Induced Hearing Loss in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, Min Soo…[et al.]. Protective Effect of Yang Mi Ryung® Extract on Noise-Induced Hearing Loss in Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1155084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, Min Soo& Kwak, SeongAe& Baek, Heumyoung& Li, Zewu& Choe, Seong-Kyu& Song, Kyung. Protective Effect of Yang Mi Ryung® Extract on Noise-Induced Hearing Loss in Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1155084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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