Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer

المؤلفون المشاركون

Tang, Meng-Jun
Ding, Shu-Bo
Hu, Wang-Yuan

المصدر

Gastroenterology Research and Practice

العدد

المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2019-11-13

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الأمراض

الملخص EN

Background.

Fibrinogen (Fib) and albumin (Alb) levels are indicators of systemic inflammatory responses.

Elevated Fib and decreased Alb levels are considered negative prognostic factors in different types of cancer.

Here, we explored the prognostic value of changes in pre- and post- neoadjuvant chemoradiotherapy (NCRT) plasma fibrinogen and serum albumin (FA) scores in patients with locally advanced rectal cancer (LARC).

Methods.

A total of 106 patients with LARC who underwent NCRT followed by surgical resection at Jinhua Municipal Central Hospital between 2011 and 2015 were analyzed.

In addition, plasma Fib and serum Alb levels before and after NCRT were collected.

FA scores were calculated based on the Fib and Alb levels dichotomized by clinical reference values.

Patients were classified into two groups based on the changes in FA scores during NCRT: in group A, FA scores decreased or remained unchanged (n=84), and in group B, FA scores increased (n=22).

Changes in FA scores were compared with patient outcomes.

Results.

Increased FA scores were associated with worse disease-free survival (DFS) and overall survival (OS) in patients with LARC.

The occurrence of systemic failure was higher in group B than in group A (40.9% vs.

19%, P=0.032).

In multivariate analysis, changes in FA scores, pretreatment carcinoembryonic antigen (CEA) levels, and pathologic differentiation were independent prognostic parameters for DFS and changes in FA scores and pretreatment CEA levels were independent prognostic parameters for OS.

Conclusions.

Increased FA score after NCRT was an independent negative prognostic factor for DFS and OS in patients with NCRT-treated LARC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tang, Meng-Jun& Ding, Shu-Bo& Hu, Wang-Yuan. 2019. Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155104

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tang, Meng-Jun…[et al.]. Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer. Gastroenterology Research and Practice No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1155104

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tang, Meng-Jun& Ding, Shu-Bo& Hu, Wang-Yuan. Fibrinogen and Albumin Score Changes during Preoperative Treatment Can Predict Prognosis in Patients with Locally Advanced Rectal Cancer. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1155104

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1155104